Skip to main content

Table 4 Genotype frequencies of INF-γ + 874 A/T in different species of leishmaniasis and healthy human controls

From: TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis

INF-γ 874 A/T

L. major

102 (%)

Healthy human controls

199 (%)

Genotypes

 AA

28 (27.5)

76 (38.2)

 AT

59 (57.8)

111 (55.8)

 TT

15 (14.7)

12 (6.0)

Alleles

 A

115 (56.4)

263 (66.1)

 T

89 (43.6)

135 (33.9)

Statistics

 TT + AT vs. AA (dominant)

P = 0.2

OR (95%CI)1.4 [0.8 to 2.4]

 TT vs. AA+AT (recessive)

P* = 0.02

OR (95%CI) 2.7 [1.2 to 5.9]

 T allele vs. A allele

p* = 0.02

OR (95%CI)1.5 [1.07 to2.13]

INF-γ 874 A/T

L. tropica

59 (%)

Healthy human controls

199 (%)

Genotypes

 AA

18 (30.5)

76 (38.2)

 AT

33 (56)

111 (55.8)

 TT

8 (13.5)

12 (6.0)

Alleles

 A

69 (58.5)

263 (66.1)

 T

49 (41.5)

135 (33.9)

Statistics

 TT + AT vs. AA (dominant)

P = 0.3

OR (95%CI)1.4 [0.8 to 2.6]

 TT vs. AA+AT (recessive)

p = 0.06

OR (95%CI) 2.4 [0.9 to 6.2]

 T allele vs. A allele

p = 0.1

OR (95%CI)1.4 [0.9 to 2.1]

INF-γ 874 A/T

L. infantum/ donovani complex

8 (%)

Healthy human controls

199 (%)

Genotypes

 AA

3 (37.5)

76 (38.2)

 AT

4 (50)

111 (55.8)

 TT

1 (12.5)

12 (6.0)

Alleles

 A

10 (62.5)

263 (66.1)

 T

6 (37.5)

135 (33.9)

Statistics

 NA

NA

NA

INF-γ 874 A/T

Totalleishmania

169(%)

Healthy human controls

199 (%)

Genotypes

 AA

49 (29)

76 (38.2)

 AT

96 (56.8)

111 (55.8)

 TT

24 (14.2)

12 (6.0)

Alleles

 A

194 (57.4)

263 (66.1)

 T

144 (42.6)

135 (33.9)

Statistics

 TT + AT vs. AA (dominant)

P = 0.06

OR (95%CI) 1.5 [1.0 to 2.3]

 TT vs. AA+AT (recessive)

p* = 0.01

OR (95%CI) 2.5 [1.2 to 5.3]

 T allele vs. A allele

p* = 0.02

OR (95%CI) 1.4 [1.07 to2.0]

  1. P* significant
  2. P** highly significant