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Table 4 Genotype frequencies of INF-γ + 874 A/T in different species of leishmaniasis and healthy human controls

From: TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis

INF-γ 874 A/TL. major
102 (%)
Healthy human controls
199 (%)
Genotypes
 AA28 (27.5)76 (38.2)
 AT59 (57.8)111 (55.8)
 TT15 (14.7)12 (6.0)
Alleles
 A115 (56.4)263 (66.1)
 T89 (43.6)135 (33.9)
Statistics
 TT + AT vs. AA (dominant)P = 0.2OR (95%CI)1.4 [0.8 to 2.4]
 TT vs. AA+AT (recessive)P* = 0.02OR (95%CI) 2.7 [1.2 to 5.9]
 T allele vs. A allelep* = 0.02OR (95%CI)1.5 [1.07 to2.13]
INF-γ 874 A/TL. tropica
59 (%)
Healthy human controls
199 (%)
Genotypes
 AA18 (30.5)76 (38.2)
 AT33 (56)111 (55.8)
 TT8 (13.5)12 (6.0)
Alleles
 A69 (58.5)263 (66.1)
 T49 (41.5)135 (33.9)
Statistics
 TT + AT vs. AA (dominant)P = 0.3OR (95%CI)1.4 [0.8 to 2.6]
 TT vs. AA+AT (recessive)p = 0.06OR (95%CI) 2.4 [0.9 to 6.2]
 T allele vs. A allelep = 0.1OR (95%CI)1.4 [0.9 to 2.1]
INF-γ 874 A/TL. infantum/ donovani complex
8 (%)
Healthy human controls
199 (%)
Genotypes
 AA3 (37.5)76 (38.2)
 AT4 (50)111 (55.8)
 TT1 (12.5)12 (6.0)
Alleles
 A10 (62.5)263 (66.1)
 T6 (37.5)135 (33.9)
Statistics
 NANANA
INF-γ 874 A/TTotalleishmania
169(%)
Healthy human controls
199 (%)
Genotypes
 AA49 (29)76 (38.2)
 AT96 (56.8)111 (55.8)
 TT24 (14.2)12 (6.0)
Alleles
 A194 (57.4)263 (66.1)
 T144 (42.6)135 (33.9)
Statistics
 TT + AT vs. AA (dominant)P = 0.06OR (95%CI) 1.5 [1.0 to 2.3]
 TT vs. AA+AT (recessive)p* = 0.01OR (95%CI) 2.5 [1.2 to 5.3]
 T allele vs. A allelep* = 0.02OR (95%CI) 1.4 [1.07 to2.0]
  1. P* significant
  2. P** highly significant