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Table 3 Genotype frequencies of TNF-α-308 G/A in different species of leishmaniasis and healthy human controls

From: TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis

TNF-α 308 G/AL. major
102 (%)
Healthy human controls
199 (%)
Genotypes
 GG60 (58.8)130 (65.3)
 GA39 (38.2)65 (32.7)
 AA3 (3.0)4 (2.0)
Alleles
 G159 (78)325 73 (81.7)
 A45 (22)73 (18.3)
Statistics
 AA+GA vs. GG (dominant)P = 0.3OR (95%CI) 1.31 [0.8 to 2.2]
 AA vs. GG + GA (recessive)P = 0.6OR (95%CI) 1.5 [0.3 to 6.7]
 A allele vs. G alleleP = 0.3OR (95%CI) 1.3 [0.8 to 1.9]
TNF-α 308 G/AL. tropica
59 (%)
Healthy human controls
199 (%)
Genotypes
 GG 35 (59.3)130 (65.3)
 GA24 (40.7)65 (32.7)
 AA0 (0)4 (2)
Alleles
 G91 (79.6)325 (81.7)
 A27 (20.4)73 (18.3)
Statistics
 AA+GA vs. GG (dominant)P = 0.4OR (95%CI) 1.3 [0.7 to 2.3]
 AA vs. GG + GA (recessive)P = 0.5OR (95%CI) 0.4 [0.02 to 7.1]
 A allele vs. G alleleP** =0.0004OR (95%CI) 2.2 [1.4 to 3.4]
TNF-α 308 G/AL. infantum/donovani complex
8 (%)
Healthy human controls
199 (%)
Genotypes
 GG5 (62.5)130 (65.3)
 GA3 (37.5)65 (32.7)
 AA0 (0)4 (2)
Alleles
 G13 (77.4)325 (81.7)
 A3 (22.6)73 (18.3)
Statistics
 NDNDND
TNF-α 308 G/ATotalleishmaniacases
169 (%)
Healthy human controls
199 (%)
Genotypes
 GG100 (59.2)130 (65.3)
 GA66 (39.1)65 (32.7)
 AA3 (1.7)4 (2)
Alleles
 G266 (78.7)325 (81.7)
 A72 (21.3)73 (18.3)
Statistics
 AA+GA vs. GG (dominant)P = 0.2OR (95%CI) 1.3 [0.9 to 2.0]
 AA vs. GG + GA (recessive)p = 0.9OR (95%CI) 0.9 [0.2 to 4.0]
 A alleles vs. G allelep = 0.3OR (95%CI) 1.2 [0.8 to 1.7]
  1. P*significant
  2. P** highly significant