Skip to main content

Table 4 OPG haplotype structure and frequencies

From: Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis

 

Haplotype frequency

Overall

Females

Males

Haplotype

Cases

Controls

p-value

Cases

Controls

p-value

Cases

Controls

p-value

A-A-C-G

62.19

48.59

0.0135

63.83

37.06

0.0001

57.65

68.42

0.2658

A-A-C-C

22.28

33.5

0.0209

21.32

42.54

0.0004

24.89

18.42

0.4373

A-A-T-G

4.39

6.42

0.4015

4.84

8.36

0.2638

29.8

5.26

0.5453

C-G-C-C

5.76

3.2

0.2958

5.49

3.76

0.5611

6.69

2.63

0.3632

C-G-T-G

0.69

1.19

0.6137

0.62

1.83

0.3465

0.97

0

0.5439

  1. Four SNPs in the following order: rs2228568, rs7844539, rs3102734, rs2073618, were used to analyze the haplotypes within the OPG gene in cases and controls. P-values are based on 10,000 permutations. Two significant haplotypes were detected: A-A-C-G and A-A-C-C (values are indicated in bold)