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Fig. 1 | BMC Medical Genetics

Fig. 1

From: Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis

Fig. 1

Schematic representation of the cellular and molecular players involved in the RANKL/RANK/OPG signaling axis in bone remodeling. The RANKL from the osteoblast-lineage cells binds to the RANK receptor on osteoclast precursor cells and promotes osteoclasts activation and differentiation, resulting in increased bone resorption. Whereas the OPG decoy receptor binds to RANKL leading to inhibition of osteoclastogenesis. OPG also functions as a decoy receptor for TRAIL, and OPG decreased production mediates the TRAIL-induced apoptosis of osteoblasts leading therefore to bone loss

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BMC Medical Genetics

ISSN: 1471-2350

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