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Table 1 Summary of the frequencies of NEGR1 and BTNL8-BTNL3 deletion

From: Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer

 

NEGR1 deletion

BTNL8-BTNL3 deletion

Calgary Cohort (n = 8)

100%

62.5%

CBTTC (n = 73)

86.3%

17.8%

MSSNG controls (n = 2596)

87.1%

48.0%

1000 Genomes Project (n = 2504)

89%

38.2%

Personal Genome Project Canada (n = 93)

77.4%

48.4%

  1. Datasets include the Calgary cohort, a pediatric HGG dataset from the CBTTC and individuals from the general population (coded parental control Canadian samples in MSSNG); 1000 Genomes Project CNVs obtained from the Database of Genomic Variants [DGV]; and control samples from Personal Genome Project Canada (PGPC)). Deletions are either heterozygous or homozygous
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BMC Medical Genetics

ISSN: 1471-2350

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