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Table 2 Overall meta-analysis of the association of IL28B polymorphisms with persistent HBV infection

From: Association between IL28B Polymorphisms and Outcomes of Hepatitis B Virus Infection: A meta-analysis

SNP Model Ethnicity Studies Number OR Heterogeneity Publication bias ORS
OR (95% CI) POR I2 (%) PH M PBegg PEgger
rs12979860 Allelic Total 11 1.03 (0.94, 1.13) 0.528 24.6 0.210 F 0.010 0.015 1.06 (0.97, 1.17)
  Asian 7 1.01 (0.87, 1.17) 0.863 33.1 0.175 R 0.069 0.032 1.07 (0.96, 1.21)
  Chinese 5 1.07 (0.95,1.21) 0.245 0.0 0.476 F 0.233 0.237 Not necessary
Dominant Total 15 0.86 (0.76, 1.00) 0.050 37.2 0.073 R 0.016 0.003 0.91 (0.78, 1.06)
  Asian 11 0.83 (0.68, 1.00) 0.051 44.7 0.053 R 0.006 < 0.001 0.95 (0.73, 1.26)
  Chinese 9 0.84 (0.69, 1.02) 0.081 40.8 0.095 R 0.045 0.001 0.98 (0.76, 1.26)
Recessive Total 7 1.14 (0.76, 1.70) 0.526 0.0 0.504 F 0.562 0.200 Not necessary
  Asian 4 0.76 (0.27, 2.17) 0.611 0.0 0.513 F 1.000 0.415 Not necessary
  Chinese 3 0.56 (0.17, 1.87) 0.350 0.0 0.526 F 1.000 0.327 Not necessary
rs12980275 Dominant Total 8 1.15 (0.96, 1.38) 0.135 32.5 0.168 R 0.399 0.177 Not necessary
  Asian 6 1.00 (0.84, 1.20) 0.966 0.0 0.795 F 0.469 0.453 Not necessary
  Chinese 5 0.98 (0.80, 1.22) 0.890 0.0 0.689 F 0.483 0.495 Not necessary
rs8099917 Dominant Total 11 1.00 (0.83, 1.20) 0.992 41.2 0.074 R 0.002 < 0.001 1.15 (0.96, 1.39)
  Asian 9 0.90 (0.75, 1.09) 0.284 11.0 0.343 F 0.006 0.006 0.99 (0.83, 1.18)
  Chinese 8 0.87 (0.71, 1.08) 0.214 18.5 0.283 F 0.0141 0.006 0.98 (0.81, 1.19)
  1. SNP single nucleotide polymorphism, M model for meta-analysis, F Fixed-effects model, R Random-effects model, PHP-value for heterogeneity test, PORP-value for OR test, PBeggP-value for Begg’s test, PEggerP-value for Egger’s test, ORS OR derived from trim and fill sensitive analysis