Association between IL28B Polymorphisms and Outcomes of Hepatitis B Virus Infection: A meta-analysis

BMC Medical Genetics

Table 2 Overall meta-analysis of the association of IL28B polymorphisms with persistent HBV infection

SNP	Model	Ethnicity	Studies Number	OR		Heterogeneity			Publication bias		OR_S
SNP	Model	Ethnicity	Studies Number	OR (95% CI)	P_OR	I² (%)	P_H	M	P_Begg	P_Egger	OR_S
rs12979860	Allelic	Total	11	1.03 (0.94, 1.13)	0.528	24.6	0.210	F	0.010	0.015	1.06 (0.97, 1.17)
		Asian	7	1.01 (0.87, 1.17)	0.863	33.1	0.175	R	0.069	0.032	1.07 (0.96, 1.21)
		Chinese	5	1.07 (0.95,1.21)	0.245	0.0	0.476	F	0.233	0.237	Not necessary
	Dominant	Total	15	0.86 (0.76, 1.00)	0.050	37.2	0.073	R	0.016	0.003	0.91 (0.78, 1.06)
		Asian	11	0.83 (0.68, 1.00)	0.051	44.7	0.053	R	0.006	< 0.001	0.95 (0.73, 1.26)
		Chinese	9	0.84 (0.69, 1.02)	0.081	40.8	0.095	R	0.045	0.001	0.98 (0.76, 1.26)
	Recessive	Total	7	1.14 (0.76, 1.70)	0.526	0.0	0.504	F	0.562	0.200	Not necessary
		Asian	4	0.76 (0.27, 2.17)	0.611	0.0	0.513	F	1.000	0.415	Not necessary
		Chinese	3	0.56 (0.17, 1.87)	0.350	0.0	0.526	F	1.000	0.327	Not necessary
rs12980275	Dominant	Total	8	1.15 (0.96, 1.38)	0.135	32.5	0.168	R	0.399	0.177	Not necessary
		Asian	6	1.00 (0.84, 1.20)	0.966	0.0	0.795	F	0.469	0.453	Not necessary
		Chinese	5	0.98 (0.80, 1.22)	0.890	0.0	0.689	F	0.483	0.495	Not necessary
rs8099917	Dominant	Total	11	1.00 (0.83, 1.20)	0.992	41.2	0.074	R	0.002	< 0.001	1.15 (0.96, 1.39)
		Asian	9	0.90 (0.75, 1.09)	0.284	11.0	0.343	F	0.006	0.006	0.99 (0.83, 1.18)
		Chinese	8	0.87 (0.71, 1.08)	0.214	18.5	0.283	F	0.0141	0.006	0.98 (0.81, 1.19)

SNP single nucleotide polymorphism, M model for meta-analysis, F Fixed-effects model, R Random-effects model, P_HP-value for heterogeneity test, P_ORP-value for OR test, P_BeggP-value for Begg’s test, P_EggerP-value for Egger’s test, OR_S OR derived from trim and fill sensitive analysis

ISSN: 1471-2350