Table 1 Characteristics of included studies in the meta-analysis
From: Association between IL28B Polymorphisms and Outcomes of Hepatitis B Virus Infection: A meta-analysis
Author | Years/countries | Ethnicity | Sources | SNPs | Genotypes | Sample size | HWE in control | NOS score | ||
|---|---|---|---|---|---|---|---|---|---|---|
Healthy control | HBV recovery | HBV persistence | ||||||||
Martin MP [20] | 2010/United States | Caucasian | Hospital-based | rs12979860 | CC/CT/TT T vs C | – | 157/175/52 279 vs 489 | 99/94/33 160 vs 292 | 0.77 | 7 |
L.J.Peng [21] | 2011/China | Asian | Population-based | rs12979860 | CC/CT + TT | – | 206/22 | 574/77 | > 0.05 | 8 |
Li WY [22] | 2011/China | Asian | Hospital-based | rs12979860 | CC/CT + TT | 179/24 | 180/23 | 178/25 | > 0.05 | 8 |
rs12980275 | AA/AG + GG | 178 vs 25 | 181/22 | 179/24 | > 0.05 |  | ||||
rs8099917 | TT/GT + GG | 182/21 | 182/21 | 180/23 | > 0.05 |  | ||||
Fabris C [23] | 2011/Italy | Caucasian | Population-based | rs12979860 | CC/CT/TT T vs C | 164/145/35 215 vs 473 | – | 36/35/4 43 vs 107 | 0.386 | 8 |
Chen J [24] | 2012/China | Asian | Population-based | rs12979860 | CC/CT/TT T vs C | 213/29/2 33 vs 455 | – | 1043/152/10 172 vs 2238 | 0.37 | 8 |
rs12980275 | AA/AG/GG G vs A | 210/33/1 35 vs 453 | – | 1036/162/8 178 vs 2234 | > 0.05 |  | ||||
rs8099917 | GG/GT/TT G vs T | 218/25/1 27 vs 461 | – | 1075/126/4 130 vs 2276 | > 0.05 |  | ||||
Ren S [19] | 2012/China | Asian | Hospital-based | rs12979860 | CC/CT/TT T vs C | 43/4/0 4 vs 90 | 33/7/3 13 vs 73 | 177/46/16 78 vs 400 | 0.01 | 8 |
rs12980275 | AA/AG/GG G vs A | 43/3/1 5 vs 89 | 37/5/1 7 vs 79 | 205/30/4 38 vs 440 | 0.01 | Â | ||||
rs8099917 | GG/GT/TT G vs T | 44/2/1 4 vs 90 | 33/6/4 14 vs 72 | 197/31/11 53 vs 425 | 0.07 | Â | ||||
Luz MC [25] | 2012/Spain | Caucasian | Hospital-based | rs12979860 | CC/CT/TT T vs C | – | 22/21/6 33 vs 65 | 29/17/3 23 vs 75 | 0.78 | 7 |
Lee DH [26] | 2013/South Korea | Asian | Hospital-based | rs12979860 | T vs C | – | 24 vs 380 | 62 vs 973 | > 0.05 | 7 |
rs12980275 | G vs A | – | 27 vs 377 | 70 vs 965 | > 0.05 |  | ||||
rs8099917 | G vs T | – | 22 vs 382 | 56 vs 979 | > 0.05 |  | ||||
Al-Qahtani [27] | 2013/Saudi Arabia | Caucasian | Hospital-based | rs12979860 | CC/CT/TT T vs C | – | 174/91/20 131 vs 439 | 450/274/92 458 vs 1174 | > 0.05 | 7 |
rs12980275 | AA/AG/GG G vs A | – | 175/93/36 165 vs 443 | 548/229/44 317 vs 1325 | > 0.05 |  | ||||
rs8099917 | GG/GT/TT G vs T | – | 15/73/216 103 vs 505 | 31/187/606 249 vs 1399 | > 0.05 |  | ||||
Kim SU [13] | 2013/South Korea | Asian | Hospital-based | rs12979860 | CC/CT/TT T vs C | 85/15/0 15 vs 185 | 189/31/0 31 vs 409 | 144/10/0 10 vs 298 | > 0.05 | 7 |
rs12980275 | AA/AG/GG G vs A | 90/16/0 16 vs 196 | 208/34/1 36 vs 450 | 185/18/0 18 vs 388 | > 0.05 |  | ||||
rs8099917 | GG/GT/TT G vs T | 90/16/0 16 vs 196 | 215/26/0 26 vs 456 | 192/12/0 12 vs 396 | > 0.05 |  | ||||
Seto WK [28] | 2013/China | Asian | Hospital-based | rs12979860 | T vs C | – | 11 vs 192 | 14 vs 189 | > 0.05 | 7 |
rs8099917 | G vs T | – | 13 vs 190 | 15 vs 188 | > 0.05 |  | ||||
Senem CK [29] | 2014/Turkey | Caucasian | Population-based | rs12979860 | CC/CT/TT T vs C | – | 46/65/6 77 vs 157 | 215/201/57 315 vs 631 | > 0.05 | 7 |
rs12980275 | AA/AG/GG G vs A | – | 36/67/15 97 vs 139 | 191/207/58 323 vs 589 | > 0.05 |  | ||||
Akkiz H [30] | 2014/Turkey | Caucasian | Hospital-based | rs12979860 | CC/CT/TT T vs C | 92/91/25 141 vs 275 | – | 43/50/17 84 vs 136 | 0.30 | 7 |
Liao Y [31] | 2014/ China | Asian | Hospital-based | rs12979860 | CC/CT + TT T vs C | – | 420/66 66 vs 906 | 391/66 70 vs 844 | > 0.05 | 8 |
rs12980275 | AA/AG + GG G vs A | – | 418/68 68 vs 904 | 388/69 77 vs 842 | > 0.05 |  | ||||
rs8099917 | GG/GT + TT G vs T | – | 470/16 16 vs 956 | 433/24 24 vs 890 | > 0.05 |  | ||||
Shi XD [32] | 2015/China | Asian | Population-based | rs12979860 | CC/CT/TT T vs C | 19/0/0 0 vs 38 | – | 114/23/0 23 vs 251 | > 0.05 | 7 |
Kimkong [33] | 2015/Thailand | Asian | Hospital-based | rs12979860 | CC/CT/TT T vs C | – | 140/24/0 24 vs 304 | 116/12/0 12 vs 244 | > 0.05 | 7 |
rs8099917 | GG/GT/TT G vs T | – | 0/25/139 25 vs 303 | 0/8/120 8 vs 248 | > 0.05 |  | ||||
Song YZ [14] | 2017/China | Asian | Hospital-based | rs12979860 | CC/CT/TT T vs C | 400/57/3 63 vs 857 | – | 439/52/2 56 vs 930 | 0.79 | 7 |
rs12980275 | AA/AG/GG G vs A | 398/58/4 66 vs 854 | – | 437/55/1 57 vs 929 | 0.50 |  | ||||
rs8099917 | GG/GT/TT G vs T | 2/52/406 56 vs 864 | – | 1/49/443 51 vs 935 | > 0.05 |  | ||||
Baghbani JM [34] | 2017/Iran | Caucasian | Hospital-based | rs12979860 | CC/CT/TT T vs C | – | 28/49/17 83 vs 105 | 31/44/8 60 vs 106 | > 0.05 | 7 |
rs8099917 | GG/GT/TT G vs T | – | 9/32/53 50 vs 138 | 4/17/62 25 vs 141 | > 0.05 |  | ||||