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Fig. 3 | BMC Medical Genetics

Fig. 3

From: Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia: a case report

Fig. 3

Genetics individual 2. a Pedigree. Individual 2 (arrow) has situs inversus (black) and DD (gray). The father has self-reported DD, but the dyslexia diagnosis is not confirmed (question mark). Unaffected individuals are shown in white. The genotypes of the variant in DNAH11 are indicated (A > G denotes c.9110A > G, Wt denotes wildtype). b Sanger DNA sequencing chromatogram of individual 2 and controls (2 unaffected siblings). c Schematic representation of the domain structure of DNAH11 and localization of the amino acid substitution p.(H3037R). N=N-terminus, C=C-terminus, P1-P4 = P-loops 1–4, MTB = microtubule domain, AAA1–6 = AAA modules 1–6

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