No association between the Ser9Gly polymorphism of the dopamine receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies

Li, Xiao-na; Zheng, Ji-long; Wei, Xiao-han; Wang, Bao-jie; Yao, Jun

doi:10.1186/s12881-020-01018-w

Table 1 Meta-analysis of TDT studies of the association between DRD3 Ser9Gly and schizophrenia

From: No association between the Ser9Gly polymorphism of the dopamine receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies

Author	Year	Location	Ethnicity	Diagnostic criteria	Number of transmissions	Ser9 allele		Expected distribution		OR	95% CI	Z-value	P-value
Author	Year	Location	Ethnicity	Diagnostic criteria	Number of transmissions	T	NT	T	NT	OR	95% CI	Z-value	P-value
Macciardi⁴¹	1994	Italy	Caucasian	DSM-III-R	108	57	51	54	54	1.118	0.766–1.630	0.577	0.564
Rothschild⁴²	1996	USA	Caucasian	DSM-III-R	71	43	28	35.5	35.5	1.536	0.959–2.459	1.786	0.074
Malhotra⁴³	1998	USA	Caucasian	DSM-III-R	149	74	75	74.5	74.5	0.987	0.716–1.360	−0.082	0.935
Kalsi⁴⁴	1998	British and Iceland	Caucasian	DSM-III-R	78	33	45	39	39	0.733	0.469–1.146	−1.361	0.173
Williams²⁶	1998	Europe	Caucasian	DSM-III-R	160	84	76	80	80	1.105	0.811–1.507	0.633	0.527
Ambrósio⁴⁵	2004	Portugal	Caucasian	DSM-IV	74	35	39	37	37	0.897	0.569–1.416	−0.465	0.642
Lu⁴⁶	2005	China	East Asian	CCMD-III	162	68	94	81	81	0.723	0.531–0.986	−2.047	0.041
Wang⁴⁷	2006	China	East Asian	CCMD-III	42	19	23	21	21	0.826	0.451–1.515	−0.618	0.537
Talkowski⁴⁸	2006	USA	Caucasian	DSM-IV	125	71	54	62.5	62.5	1.315	0.924–1.870	1.523	0.128
Talkowski⁴⁸	2006	India	Indian	DSM-IV	130	70	60	65	65	1.167	0.827–1.646	0.877	0.380
Pawel⁴⁹	2010	Poland	Caucasian	DSM-IV, ICD-10	120	57	63	60	60	0.905	0.632–1.294	−0.548	0.584
Subgroup of East Asian					204	87	117	102	102	0.744	0.564–0.980	−2.104	0.035
Subgroup of Caucasian					885	454	431	442.5	442.5	1.053	0.923–1.202	0.771	0.441
Subgroup of DSM-III-R					566	291	275	283	283	1.058	0.897–1.248	0.673	0.501
Subgroup of DSM-IV					449	233	216	224.5	224.5	1.079	0.897–1.298	0.803	0.422
Subgroup of CCMD-III					204	87	117	102	102	0.744	0.564–0.980	−2.104	0.035
Total					1219	611	608	609.5	609.5	1.005	0.898–1.125	0.086	0.932

Note: T, transmitted (number of times the allele is transmitted from heterozygous parents to the proband); NT, not transmitted

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ISSN: 1471-2350

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