Table 6 Genotype and allelic frequency, the OR[95%CI] and P-value of risk allele compared to wild allele at three categories of Gleason score
rs4242382 | Â | AA n (%) | AG n (%) | GG n (%) | A | G | OR (95%CI) | P-Value |
|---|---|---|---|---|---|---|---|---|
Control |  | 0 (0) | 6 (6) | 94 (94) | 6 (0.03) | 194 (0.97) | 1(reference) | – |
Gleason score | < 7 | 0 (0) | 5 (35.7) | 9 (64.3) | 5 (0.178) | 23 (0.821) | 7.029 (1.988–24.856) | 0.005 |
7 | 0 (0) | 8 (17) | 39 (83) | 8 (0.08) | 86 (0.91) | 3.008 (1.013–8.933) | 0.039 | |
≥8 | 1 (2.4) | 10 (23.8) | 31 (73.8) | 12 (0.14) | 72 (0.85) | 5.389 (1.95–14.894) | 0.00 | |
rs2735839 | Â | AA | AG | GG | A | G | OR (95%CI) | P-Value |
Control |  | 1 (1) | 12 (12) | 87 (87) | 14 (0.07) | 186 (0.93) | 1(reference) | – |
Gleason score | < 7 | 0 (0) | 7 (50) | 7 (50) | 7 (0.25) | 21 (0.75) | 4.429 (1.608–12.199) | 0.007 |
7 | 1 (2.1) | 15 (31.9) | 31 (66) | 17 (0.18) | 77 (0.81) | 2.933 (1.378–6.244) | 0.004 | |
≥8 | 2 (4.8) | 19 (45.2) | 21 (50) | 23 (0.27) | 61 (0.72) | 5.009 (2.427–10.339) | 0.00 | |
rs1447295 | Â | AA | AC | CC | A | C | OR (95%CI) | P-Value |
Control |  | 0 (0) | 6 (6) | 94 (94) | 6 (0.03) | 194 (0.97) | 1(reference) | – |
Gleason score | < 7 | 0 (0) | 3 (21.4) | 11 (78.6) | 3 (0.107) | 25 (0.89) | 3.88 (0.913–16.494) | 0.084 |
7 | 0 (0) | 8 (17) | 39 (83) | 8 (0.08) | 86 (0.91) | 3.008 (1–8.933) | 0.073 | |
≥8 | 0 (0) | 8 (21) | 30 (78.9) | 8 (0.105) | 68 (0.89) | 3.804 (1.274–11.359) | 0.026 |