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Table 4 Pooling data regarding the association between MUC5B rs35705950 and pneumonia risk

From: Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

Genetic modelSubgroupSample sizeAssociation
StudyCase/controlOR (95% CI)PassociationBonferroni-PassociationFDR-Passociation
Allelic T vs. GOverall315644/14,6243.78 [3.25,4.39]< 0.001< 0.006< 0.0010
Caucasian152556/52314.23 [3.57,5.02]< 0.001< 0.006< 0.0010
Asian6582/46722.76 [1.67,4.56]< 0.001< 0.006< 0.0010
PB294074/12,6163.69 [3.15,4.32]< 0.001< 0.006< 0.0010
IPF194776/90314.03 [3.38,4.81]< 0.001< 0.006< 0.0010
NSIP4295/16073.01 [1.79,5.08]< 0.001< 0.006< 0.0015
Carrier T vs. GOverall213138/99033.31 [3.01,3.65]< 0.001< 0.006< 0.0010
Caucasian152556/52313.35 [3.03,3.70]< 0.001< 0.006< 0.0010
Asian6582/46722.47 [1.52,4.02]< 0.001< 0.006< 0.0010
PB201628/80293.10 [2.69,3.57]< 0.001< 0.006< 0.0010
IPF132601/57723.43 [3.10,3.80]< 0.001< 0.006< 0.0010
NSIP4295/16072.66 [1.66,4.26]< 0.001< 0.006< 0.0015
TT vs. GGOverall152556/523113.66 [10.01,18.63]< 0.001< 0.006< 0.0010
Caucasian152556/523112.66 [10.01,18.63]< 0.001< 0.006< 0.0010
PB141046/335710.45 [6.66,16.37]< 0.001< 0.006< 0.0010
IPF112392/444913.87 [10.08,19.09]< 0.001< 0.006< 0.0010
NSIP274/28412.29 [1.61,93.86]0.016< 0.096< 0.0015
GT vs. GGOverall213138/99034.78 [3.76,6.06]< 0.001< 0.006< 0.0010
Caucasian152556/52315.33 [4.20,6.77]< 0.001< 0.006< 0.0010
Asian6582/46722.78 [1.66,4.65]< 0.001< 0.006< 0.0010
PB201628/80294.56 [3.60,5.78]< 0.001< 0.006< 0.0010
IPF132601/57726.35 [5.49,7.34]< 0.001< 0.006< 0.0010
NSIP4295/16072.91 [1.72,4.92]0.0100.0600.0120
GT + TT vs. GGOverall213138/99035.05 [3.96,6.45]< 0.001< 0.006< 0.0010
Caucasian152556/52315.70 [4.46,7.27]< 0.001< 0.006< 0.0010
Asian6582/46722.78 [1.66,4.65]< 0.001< 0.006< 0.0010
PB201628/80294.82 [3.78,6.16]< 0.001< 0.006< 0.0010
IPF132601/57726.49 [5.48,7.68]< 0.001< 0.006< 0.0010
NSIP4295/16073.19 [1.75,5.83]< 0.001< 0.006< 0.0015
TT vs. GG + GTOverall152556/52316.47 [4.77,8.77]< 0.001< 0.006< 0.0010
Caucasian152556/52316.47 [4.77,8.77]< 0.001< 0.006< 0.0010
PB141046/33575.76 [3.76,8.85]< 0.001< 0.006< 0.0010
IPF112392/44496.45 [4.72,8.81]< 0.001< 0.006< 0.0010
NSIP274/2848.41 [1.11,63.80]0.0400.2400.0400
  1. PB population-based, IPF idiopathic pulmonary fibrosis, NSIP nonspecific interstitial pneumonia, OR odds ratio, CI 95% confidence interval, PassociationP value in the association test, Bonferroni-Passociation Bonferroni-adjusted P value in the association test, FDR-Passociation false discovery rate adjusted-P value in the association test
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BMC Medical Genetics

ISSN: 1471-2350

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