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Table 4 Pooling data regarding the association between MUC5B rs35705950 and pneumonia risk

From: Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

Genetic model

Subgroup

Sample size

Association

Study

Case/control

OR (95% CI)

Passociation

Bonferroni-Passociation

FDR-Passociation

Allelic T vs. G

Overall

31

5644/14,624

3.78 [3.25,4.39]

< 0.001

< 0.006

< 0.0010

Caucasian

15

2556/5231

4.23 [3.57,5.02]

< 0.001

< 0.006

< 0.0010

Asian

6

582/4672

2.76 [1.67,4.56]

< 0.001

< 0.006

< 0.0010

PB

29

4074/12,616

3.69 [3.15,4.32]

< 0.001

< 0.006

< 0.0010

IPF

19

4776/9031

4.03 [3.38,4.81]

< 0.001

< 0.006

< 0.0010

NSIP

4

295/1607

3.01 [1.79,5.08]

< 0.001

< 0.006

< 0.0015

Carrier T vs. G

Overall

21

3138/9903

3.31 [3.01,3.65]

< 0.001

< 0.006

< 0.0010

Caucasian

15

2556/5231

3.35 [3.03,3.70]

< 0.001

< 0.006

< 0.0010

Asian

6

582/4672

2.47 [1.52,4.02]

< 0.001

< 0.006

< 0.0010

PB

20

1628/8029

3.10 [2.69,3.57]

< 0.001

< 0.006

< 0.0010

IPF

13

2601/5772

3.43 [3.10,3.80]

< 0.001

< 0.006

< 0.0010

NSIP

4

295/1607

2.66 [1.66,4.26]

< 0.001

< 0.006

< 0.0015

TT vs. GG

Overall

15

2556/5231

13.66 [10.01,18.63]

< 0.001

< 0.006

< 0.0010

Caucasian

15

2556/5231

12.66 [10.01,18.63]

< 0.001

< 0.006

< 0.0010

PB

14

1046/3357

10.45 [6.66,16.37]

< 0.001

< 0.006

< 0.0010

IPF

11

2392/4449

13.87 [10.08,19.09]

< 0.001

< 0.006

< 0.0010

NSIP

2

74/284

12.29 [1.61,93.86]

0.016

< 0.096

< 0.0015

GT vs. GG

Overall

21

3138/9903

4.78 [3.76,6.06]

< 0.001

< 0.006

< 0.0010

Caucasian

15

2556/5231

5.33 [4.20,6.77]

< 0.001

< 0.006

< 0.0010

Asian

6

582/4672

2.78 [1.66,4.65]

< 0.001

< 0.006

< 0.0010

PB

20

1628/8029

4.56 [3.60,5.78]

< 0.001

< 0.006

< 0.0010

IPF

13

2601/5772

6.35 [5.49,7.34]

< 0.001

< 0.006

< 0.0010

NSIP

4

295/1607

2.91 [1.72,4.92]

0.010

0.060

0.0120

GT + TT vs. GG

Overall

21

3138/9903

5.05 [3.96,6.45]

< 0.001

< 0.006

< 0.0010

Caucasian

15

2556/5231

5.70 [4.46,7.27]

< 0.001

< 0.006

< 0.0010

Asian

6

582/4672

2.78 [1.66,4.65]

< 0.001

< 0.006

< 0.0010

PB

20

1628/8029

4.82 [3.78,6.16]

< 0.001

< 0.006

< 0.0010

IPF

13

2601/5772

6.49 [5.48,7.68]

< 0.001

< 0.006

< 0.0010

NSIP

4

295/1607

3.19 [1.75,5.83]

< 0.001

< 0.006

< 0.0015

TT vs. GG + GT

Overall

15

2556/5231

6.47 [4.77,8.77]

< 0.001

< 0.006

< 0.0010

Caucasian

15

2556/5231

6.47 [4.77,8.77]

< 0.001

< 0.006

< 0.0010

PB

14

1046/3357

5.76 [3.76,8.85]

< 0.001

< 0.006

< 0.0010

IPF

11

2392/4449

6.45 [4.72,8.81]

< 0.001

< 0.006

< 0.0010

NSIP

2

74/284

8.41 [1.11,63.80]

0.040

0.240

0.0400

  1. PB population-based, IPF idiopathic pulmonary fibrosis, NSIP nonspecific interstitial pneumonia, OR odds ratio, CI 95% confidence interval, PassociationP value in the association test, Bonferroni-Passociation Bonferroni-adjusted P value in the association test, FDR-Passociation false discovery rate adjusted-P value in the association test
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BMC Medical Genetics

ISSN: 1471-2350

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