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Table 3 Pooling data regarding the association between FCGR2A rs1801274 and pneumonia risk

From: Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

Genetic model

Subgroup

Sample size

Association

Study

Case/control

OR (95% CI)

Passociation

Bonferroni-Passociation

FDR-Passociation

Allelic G vs. A

Overall

13

1332/5428

1.08 [0.89,1.31]

0.450

1.000

0.6312

Caucasian

8

1049/4363

1.03 [0.87,1.22]

0.742

1.000

0.8904

PB

5

447/689

1.35 [0.88,2.08]

0.169

1.000

0.3015

HB

4

192/967

0.97 [0.60,1.58]

0.906

1.000

0.9060

Carrier G vs. A

Overall

13

1332/5428

1.05 [0.94,1.16]

0.378

1.000

0.6312

Caucasian

8

1049/4363

1.04 [0.92,1.16]

0.554

1.000

0.8904

PB

5

447/689

1.16 [0.95,1.43]

0.153

0.918

0.3015

HB

4

192/967

0.93 [0.71,1.22]

0.603

1.000

0.8364

GG vs. AA

Overall

13

1332/5428

1.13 [0.78,1.64]

0.526

1.000

0.6312

Caucasian

8

1049/4363

1.06 [0.76,1.48]

0.729

1.000

0.8904

PB

5

447/689

1.76 [0.74,4.19]

0.201

1.000

0.3015

HB

4

192/967

0.86 [0.40,1.84]

0.697

1.000

0.8364

AG vs. AA

Overall

13

1332/5428

0.87 [0.65,1.16]

0.341

1.000

0.6312

Caucasian

8

1049/4363

0.94 [0.71,1.25]

0.684

1.000

0.8904

PB

5

447/689

1.04 [0.63,1.73]

0.879

1.000

0.8790

HB

4

192/967

0.55 [0.32,0.92]

0.023

0.138

0.1380

AG + GG vs. AA

Overall

13

1332/5428

0.96 [0.72,1.30]

0.812

1.000

0.8120

Caucasian

8

1049/4363

0.98 [0.74,1.30]

0.899

1.000

0.8990

PB

5

447/689

1.27 [0.70,2.30]

0.430

1.000

0.5160

HB

4

192/967

0.67 [0.42,1.09]

0.106

0.636

0.3180

GG vs. AA + AG

Overall

14

1530/8217

1.19 [0.93,1.52]

0.178

1.000

0.6312

Caucasian

9

1247/7152

1.05 [0.85,1.29]

0.662

1.000

0.8904

PB

5

447/689

1.71 [0.94,3.13]

0.081

0.486

0.3015

HB

5

390/3756

1.12 [0.67,1.87]

0.669

1.000

0.8364

  1. PB population-based, HB hospital-based, OR odds ratio, CI 95% confidence interval, PassociationP value in the association test, Bonferroni-Passociation Bonferroni-adjusted P value in the association test, FDR-Passociation false discovery rate-adjusted P value in the association test