Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

Shi, Xueshu; Ma, Yue; Li, Haiyan; Yu, Huanxin

doi:10.1186/s12881-020-01005-1

BMC Medical Genetics

Table 1 Basic information of the studies included in the meta-analysis

From: Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

First author, Year [Ref.]	Race	Variation	Disease type	Sample		Control source	Assay
First author, Year [Ref.]	Race	Variation	Disease type	case	control	Control source	Assay
Bougle, 2012 [11]	Caucasian	rs1801274	ICU /pneummonia	198	2789	HB	Taqman
Dressen, 2018 [35]	Caucasian	rs35705950	IPF	1510	1874	HB	Sequencing
Endeman, 2009 [12]	Caucasian	rs1801274	CAP	200	313	PB	Taqman
Forthal, 2007 [13]	Mixed	rs1801274	AIDS/ pneumonia	80	478	HB	Allele-specific PCR
Horimasu, 2015 [36]	Asian	rs35705950	NSIP	30	310	PB	Taqman
			IPF	44	310	PB	Taqman
	Caucasian	rs35705950	NSIP	31	35	PB	Taqman
			IPF	71	35	PB	Taqman
Johnson, 2017 [37]	Caucasian	rs35705950	IIP	60	134	NA	Taqman
Jonsson, 2006 [14]	Caucasian	rs1801274	C2D/pneumonia	30	200	PB	Allele-specific PCR/sequencing
Kinder, 2007 [15]	Mixed	rs1801274	SLE/pneumonia	42	217	HB	Pyrosequencing
Kishore, 2016 [38]	Caucasian	rs35705950	IPF^a	41	96	PB	Sequenom MassARRAY
		rs35705950	IPF^b	33	96	PB	Sequenom MassARRAY
		rs35705950	IPF^c	36	96	PB	Sequenom MassARRAY
		rs35705950	IPF^d	51	96	PB	Sequenom MassARRAY
Ley, 2017 [39]	Mixed	rs35705950	CHP^e	123	503	PB	Taqman
			CHP^f	65	503	PB	Taqman
			IPF^e	147	503	PB	Taqman
			IPF^f	126	503	PB	Taqman
Moens, 2006 [16]	Caucasian	rs1801274	pneumonia	55	100	Mixed	allelic discrimination
Noth, 2013 [8]	Mixed	rs35705950	IPF^g	542	542	PB	Genome-Wide Human SNP array
			IPF^h	544	687	PB	iPLEX Gold Platform
			IPFⁱ	324	702	PB	iPLEX Gold Platform
Seibold, 2011 [23]	Mixed	rs35705950	IPF	492	322	PB	Sequenom iPLEX
			FIP	83	322	PB	Sequenom iPLEX
Sole, 2011 [17]	Caucasian	rs1801274	pneumococcal CAP	319	1224	Mixed	ASRED
			nonbacteremic CAP	234	1224	Mixed	ASRED
			bacteremic CAP	85	1224	Mixed	ASRED
Stock, 2013 [40]	Caucasian	rs35705950	IPF	110	416	PB	Taqman
van, 2016 [41]	Caucasian	rs35705950	spIPF	115	249	PB	Taqman
			FIP	55	249	PB	Taqman
			iNSIP	43	249	PB	Taqman
			CTD-IP	35	249	PB	Taqman
Wang, 2014 [42]	Asian	rs35705950	IPF	165	1013	PB	PCR-RFLP/Taqman/ sequencing
			CTD-NSIP	191	1013	PB	PCR-RFLP/Taqman/sequencing
			CTD-UIP	49	1013	PB	PCR-RFLP/Taqman/sequencing
			pneumonia	103	1013	PB	PCR-RFLP/Taqman/sequencing
Wei, 2014 [43]	Caucasian	rs35705950	IPF	84	689	PB	Taqman
Yee, 2000 [18]	Mixed	rs1801274	bacteremic pneumonia	42	136	HB	quantitative flow cytometry
			nonbacteremic pneumonia	28	136	HB	quantitative flow cytometry
Yuan, 2003 [19]	Caucasian	rs1801274	pneumonia	63	20	PB^#	SSP
			pneumonia	63	58	PB^%	SSP
Zhang, 2011 [44]	Caucasian	rs35705950	IPF^j	246	166	PB	Taqman
			IPF^k	95	636	PB	Taqman
Zuniga, 2012 [20]	Mixed	rs1801274	pneumonia	91	98	PB	Taqman

Ref. reference, M major allele (A for rs1801274; G for rs35705950), m minor allele (G for rs1801274; T for rs35705950), ICU intensive care unit, IPF idiopathic pulmonary fibrosis, CAP community-acquired pneumonia, AIDS acquired immune deficiency syndrome, NSIP nonspecific interstitial pneumonia, IIP idiopathic interstitial pneumonia, C2D, homozygous C2 deficiency, SLE systemic lupus erythematosus, CHP chronic hypersensitivity pneumonitis, FIP familial interstitial pneumonia, spIPF sporadic type of idiopathic pulmonary fibrosis, iNSIP idiopathic non-specific interstitial pneumonia, CTD-IP connective tissue disease associated intersititial pneumonia, CTD-NSIP connective tissue diseases-nonspecific interstitial pneumonia pattern, CTD-UIP connective tissue diseases-usual interstitial pneumonia pattern, HB hospital-based, PB population-based, NA not available, ASRED allele-specific restriction enzyme digestion, PCR polymerase chain reaction, SNP single nucleotide polymorphism, SSP sequence specific PCR, RFLP restriction fragment length polymorphism
a data of Czech Republic, b data of Germany, c data of Greece, d data of France,
e data of University of California San Francisco, f data of University of Texas Southwestern,
g stage one of genome-wide association study, h stage two of genome-wide association study,
i stage three of genome-wide association study, j data of University of Pittsburgh, k, data of University of Chicago,
# healthy control, % normal random blood donors

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ISSN: 1471-2350

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