Skip to main content

Table 5 Comparisons of clinical characteristics among genotypes rs7754840, rs7138803, and rs6548238

From: Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients

Ā 

rs7754840

P

rs7138803

P

rs6548238

CCā€‰+ā€‰CG

GG

AA+AG

GG

CCā€‰+ā€‰CT

TT

P

Waistcircumference (cm)

96.68ā€‰Ā±ā€‰17.31

90.29ā€‰Ā±ā€‰14.56

0.040

97.11ā€‰Ā±ā€‰16.42

92.53ā€‰Ā±ā€‰16.53

0.139

97.27ā€‰Ā±ā€‰16.84

90.75ā€‰Ā±ā€‰15.66

0.030

Waist/hip ratio

1.11ā€‰Ā±ā€‰0.36

0.97ā€‰Ā±ā€‰0.25

0.027

1.09ā€‰Ā±ā€‰0.30

1.04ā€‰Ā±ā€‰0.35

0.345

1.15ā€‰Ā±ā€‰0.33

0.95ā€‰Ā±ā€‰0.29

0.001

BMI (kg/m2)

26.48ā€‰Ā±ā€‰4.98

25.98ā€‰Ā±ā€‰5.80

0.612

27.94ā€‰Ā±ā€‰4.94

25.25ā€‰Ā±ā€‰5.25

0.006

26.94ā€‰Ā±ā€‰4.57

22.52ā€‰Ā±ā€‰5.98

0.023

FPG (mmol/L)

10.07ā€‰Ā±ā€‰4.00

10.14ā€‰Ā±ā€‰3.67

0.925

10.97ā€‰Ā±ā€‰3.77

9.54ā€‰Ā±ā€‰3.85

0.046

11.01ā€‰Ā±ā€‰3.80

9.01ā€‰Ā±ā€‰3.69

0.004

HbA1c, %

9.90ā€‰Ā±ā€‰3.94

9.72ā€‰Ā±ā€‰3.36

0.799

10.30ā€‰Ā±ā€‰3.74

9.53ā€‰Ā±ā€‰3.70

0.268

10.70ā€‰Ā±ā€‰4.02

8.78ā€‰Ā±ā€‰3.05

0.004

SBP (mm Hg)

132.91ā€‰Ā±ā€‰23.98

124.93ā€‰Ā±ā€‰17.85

0.039

130.00 (112.00,115.00)

122.00 (110.00,150.00)

0.413

131.39ā€‰Ā±ā€‰22.03

128.20ā€‰Ā±ā€‰22.39

0.432

DBP (mm Hg)

84.03ā€‰Ā±ā€‰11.14

82.13ā€‰Ā±ā€‰10.60

0.360

86.45ā€‰Ā±ā€‰9.91

81.34ā€‰Ā±ā€‰11.16

0.012

85.91ā€‰Ā±ā€‰9.91

80.22ā€‰Ā±ā€‰11.39

0.004

TG (mmol/L)

4.61ā€‰Ā±ā€‰4.38

4.32ā€‰Ā±ā€‰3.69

0.705

3.66 (1.98,7.13)

2.62 (1.42,4.84)

0.041

5.46ā€‰Ā±ā€‰4.80

3.36ā€‰Ā±ā€‰2.76

0.005

TC (mmol/L)

5.39ā€‰Ā±ā€‰2.60

5.38ā€‰Ā±ā€‰2.60

0.44

5.38ā€‰Ā±ā€‰2.60

4.93ā€‰Ā±ā€‰2.38

0.324

5.88ā€‰Ā±ā€‰2.45

4.51ā€‰Ā±ā€‰1.99

0.001

HDL-C (mmol/L)

1.05ā€‰Ā±ā€‰0.54

0.98ā€‰Ā±ā€‰0.47

0.455

0.92 (0.58,1.06)

0.97 (0.70,1.22)

0.066

0.85ā€‰Ā±ā€‰0.36

1.23ā€‰Ā±ā€‰0.59

0.001

LDL-C (mmol/L)

2.92ā€‰Ā±ā€‰1.01

2.37ā€‰Ā±ā€‰0.87

0.176

2.99ā€‰Ā±ā€‰0.93

2.72ā€‰Ā±ā€‰0.98

0.133

2.98ā€‰Ā±ā€‰1.04

2.63ā€‰Ā±ā€‰0.85

0.050

FINS (Ī¼IU/mL)

22.27ā€‰Ā±ā€‰17.33

17.82ā€‰Ā±ā€‰10.06

0.076

19.60 (16.56,26.72)

13.18 (8.72,26.10)

0.007

21.50ā€‰Ā±ā€‰12.51

19.55ā€‰Ā±ā€‰17.88

0.484

HOMA-IR

6.81 (2.98,14.05)

5.60 (3.59,13.86)

0.677

10.46 (3.72,15.07)

5.35 (2.90,12.68)

0.083

10.01ā€‰Ā±ā€‰8.52

8.79ā€‰Ā±ā€‰7.31

0.399

HOMA-IS

0.010 (0.000,0.020)

0.010 (0.005,0.017)

0.184

0.012 (0.010,0.020)

0.010 (0.000,0.020)

0.662

0.010 (0.000,0.010)

0.016 (0.010,0.020)

0.001