Skip to main content

Advertisement

Table 4 Clinical and metabolic characteristics of genotypes containing rs2479106, rs2768819, rs2670139, rs2536951 and rs2479102 in PCOS cases and controls

From: Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women

GenotypesControlp-valuePCOSp-value
rs2479106AGAAGGAGAAGG
Age (years)33.53 ± 0.6532.58 ± 0.4934.40 ± 2.270.77126.97 ± 0.7226.15 ± 0.6033.00 ± 0.490.227
BMI (kg/m2)22.72 ± 0.4921.51 ± 0.2623.41 ± 0.620.14323.33 ± 0.7223.06 ± 0.5419.96 ± 0.490.268
E2(pg/ml)63.06 ± 7.3657.13 ± 4.4042.87 ± 5.230.436209.61 ± 25.42256.54 ± 16.61102.19 ± 28.390.184
T(nm/l)2.93 ± 0.172.04 ± 0.321.34 ± 0.320.1473.99 ± 1.066.27 ± 2.152.84 ± 1.050.727
E2/T(ln)21.33 ± 1.7272.21 ± 25.1033.11 ± 2.870.33592.12 ± 12.4993.92 ± 12.6835.98 ± 5.490.797
LH(IU/l)5.94 ± 0.644.79 ± 0.292.56 ± 0.830.013*15.73 ± 1.3117.11 ± 1.199.79 ± 1.480.318
FSH(IU/l)8.40 ± 0.667.90 ± 0.317.00 ± 0.410.7017.17 ± 0.506.27 ± 0.336.78 ± 0.290.551
LH/FSH0.78 ± 0.070.64 ± 0.040.36 ± 0.110.007*2.99 ± 0.192.94 ± 0.201.44 ± 0.120.068
PRL(μg/l)4.67 ± 1.356.31 ± 1.781.79 ± 0.030.72414.62 ± 1.5918.21 ± 2.105.75 ± 1.050.365
rs2768819Controlp-valuePCOSp-value
AGAAGG AGAAGG
Age (years)32.6 ± 0.7733.58 ± 0.5134.00 ± 1.000.93528.63 ± 0.8427.24 ± 0.8022.5 ± 0.650.269
BMI (kg/m2)22.7 ± 0.5921.93 ± 0.3221.69 ± 2.790.46513.52 ± 0.8823.30 ± 0.7919.72 ± 0.860.678
E2(pg/ml)62.7 ± 8.6561.36 ± 5.2756.36 ± 25.640.983197.51 ± 32.63192.59 ± 17.67250.90 ± 30.350.899
T(nm/l)2.71 ± 0.332.09 ± 0.141.67 ± 0.650.3392.01 ± 0.152.55 ± 0.263.35 ± 0.640.225
E2/T(ln)20.5 ± 3.3772.51 ± 10.7532.75 ± 2.510.241109.08 ± 16.6675.45 ± 15.5584.77 ± 17.940.917
LH(IU/l)5.45 ± 0.525.19 ± 0.344.58 ± 1.410.90511.75 ± 1.2616.66 ± 1.6131.70 ± 2.340.013*
FSH(IU/l)6.59 ± 0.288.04 ± 0.388.42 ± 0.440.0576.58 ± 0.547.06 ± 0.506.21 ± 0.540.779
LH/FSH0.89 ± 0.090.68 ± 0.040.54 ± 0.140.2221.85 ± 0.162.44 ± 0.215.26 ± 0.690.002*
PRL(μg/l)4.58 ± 2.917.64 ± 2.181.80 ± 0.060.58315.16 ± 1.6919.53 ± 3.7124.43 ± 1.330.618
rs2536951Controlp-valuePCOSp-value
AGAAGGAGAAGG
Age (years)33.3 ± 0.9932.61 ± 0.5232.30 ± 0.960.66727.43 ± 0.6825.98 ± 0.6230.00 ± 2.000.166
BMI (kg/m2)22.3 ± 0.6121.71 ± 0.3121.44 ± 0.800.44223.41 ± 0.7922.99 ± 0.5826.89 ± 3.160.413
E2(pg/ml)61.0 ± 6.0356.40 ± 4.5159.45 ± 12.170.861217.63 ± 29.31247.00 ± 19.28232.68 ± 80.200.699
T(nm/l)2.85 ± 0.372.28 ± 0.361.09 ± 0.070.2683.43 ± 0.834.01 ± 0.482.12 ± 0.560.67
E2/T(ln)20.7 ± 9.8070.70 ± 27.7428.84 ± 1.410.41293.06 ± 14.9389.39 ± 12.39107.24 ± 9.500.947
LH(IU/l)6.19 ± 0.515.07 ± 0.385.25 ± 0.700.28415.74 ± 1.4717.21 ± 1.3712.58 ± 2.020.739
FSH(IU/l)8.10 ± 0.598.14 ± 0.377.70 ± 0.790.936.77 ± 0.516.36 ± 0.387.36 ± 0.710.65
LH/FSH0.88 ± 0.070.64 ± 0.040.72 ± 0.080.026*2.35 ± 0.172.91 ± 0.211.75 ± 0.440.139
PRL(μg/l)1.73 ± 0.695.09 ± 1.853.79 ± 0.630.9813.15 ± 1.5518.21 ± 2.3618.33 ± 8.650.358
rs2479102Controlp-valuePCOSp-value
CTCCTTCTCCTT
Age (years)33.2 ± 0.7133.40 ± 1.0632.80 ± 0.500.56127.56 ± 0.7423.33 ± 2.6026.60 ± 0.630.218
BMI (kg/m2)22.3 ± 0.5522.94 ± 1.0521.64 ± 0.260.19723.40 ± 0.9020.25 ± 1.8823.48 ± 0.610.443
E2(pg/ml)62.4 ± 7.3047.53 ± 4.7359.70 ± 4.790.525190.30 ± 26.79215.11 ± 31.41240.79 ± 20.580.35
T(nm/l)2.75 ± 0.331.20 ± 0.102.16 ± 0.290.1913.24 ± 0.892.48 ± 0.523.36 ± 0.450.915
E2/T(ln)21.9 ± 3.8824.52 ± 3.6664.40 ± 21.940.37484.89 ± 12.4589.30 ± 7.27103.02 ± 14.290.702
LH(IU/l)5.68 ± 0.585.06 ± 0.605.04 ± 0.350.61914.86 ± 1.6121.22 ± 5.0215.56 ± 1.140.424
FSH(IU/l)7.90 ± 0.619.02 ± 0.907.86 ± 0.340.1296.94 ± 0.476.06 ± 0.306.32 ± 0.390.594
LH/FSH0.80 ± 0.070.59 ± 0.070.67 ± 0.040.2432.13 ± 0.183.55 ± 0.912.72 ± 0.220.092
PRL(μg/l)4.64 ± 3.353.79 ± 0.635.76 ± 1.640.90213.82 ± 1.5722.26 ± 7.0718.52 ± 2.490.38
rs2670139Controlp-valuePCOSp-value
CTCCTTCTCCTT
Age (years)33.2 ± 0.6732.79 ± 1.1132.66 ± 0.510.80727.59 ± 0.7125.50 ± 2.5026.12 ± 0.600.318
BMI (kg/m2)22.20 ± 0.522.33 ± 1.1721.61 ± 0.250.45823.40 ± 0.8321.73 ± 2.0123.20 ± 0.550.857
E2(pg/ml)57.9 ± 6.9860.14 ± 12.7055.72 ± 3.410.89214.98 ± 29.90201.58 ± 49.11250.40 ± 17.800.536
T(nm/l)2.81 ± 0.312.15 ± 0.752.01 ± 0.260.1983.37 ± 0.852.46 ± 0.906.37 ± 2.040.592
E2/T(ln)22.0 ± 3.8923.19 ± 7.5566.16 ± 23.760.37195.37 ± 15.3786.28 ± 11.4591.78 ± 11.840.979
LH(IU/l)5.39 ± 1.004.84 ± 1.495.03 ± 0.350.78614.86 ± 1.5122.83 ± 8.2417.63 ± 1.230.945
FSH(IU/l)7.65 ± 1.108.23 ± 2.358.09 ± 0.360.1296.57 ± 0.476.27 ± 0.386.73 ± 0.360.272
LH/FSH0.78 ± 0.140.63 ± 0.160.64 ± 0.040.4762.29 ± 0.193.73 ± 1.542.83 ± 0.200.138
PRL(μg/l)2.53 ± 0.771.79 ± 0.044.63 ± 1.420.76912.82 ± 1.3716.33 ± 6.6518.17 ± 2.160.294
  1. *P < 0.05. Statistical analyses were carried out by analysis of covariance to correct for age and BMI. Data are expressed as mean ± standard deviation. BMI body mass index, E2 estradiol, T testosterone, LH luteinizing hormone, FSH follicle-stimulating hormone