Table 4 Distribution of alleles and genotypes of angiotensin-converting enzyme insertion/deletion (I/D) polymorphism with respect to patient characteristics in psoriasis
Variable (no. of study) | II | ID | DD | I | D | OR (95%CI), P-value |
|---|---|---|---|---|---|---|
Sex (3) | ||||||
Male (n = 194) vs. Female (n = 180) | 41 (21%) vs. 42 (23%) | 102 (53%) vs. 87 (49%) | 51 (26%) vs. 51 (28%) | 184 (47.4%) vs. 171 (47.5%) | 204 (52.6%) vs. 189 (52.5%) | 0.99 (0.74, 1.33), 0.983 |
Family history (6) | ||||||
Positive (n = 506) vs. Negative (n = 685) | 224 (44%) vs. 223 (32%) | 194 (38%) vs. 308 (45%) | 88 (18%) vs. 154 (22%) | 642 (63.4%) vs. 754 (55%) | 370 (36.6%) vs. 616 (45%) | 1.44 (1.24, 1.67), < 0.001 |
Age at onset (9) | ||||||
Early-onset (n = 1522) vs. Late-onset (n = 715) | 516 (33.9%) vs. 265 (37.1%) | 666 (43.8%) vs. 298 (41.7%) | 340 (22.3%) vs. 152 (21.2%) | 1698 (55.8%) vs. 828 (57.9%) | 1346 (44.2%) vs. 602 (42.1%) | 0.93 (0.82, 1.04), 0.208 |
Type of psoriasis (2) | ||||||
Type Ӏ (n = 256) vs. Type ӀӀ (n = 204) | 151 (59%) vs. 109 (53.4%) | 90 (35.2%) vs. 71 (34.8%) | 15 (5.8%) vs. 24 (11.8%) | 392 (76.6%) vs. 289 (71%) | 120 (23.4%) vs. 119 (39%) | 1.31 (0.99, 1.74), 0.060 |
Severity (3) | ||||||
Mild (n = 807) vs. Severe (n = 202) | 332 (41.1%) vs. 74 (36.6%) | 355 (44%) vs. 71 (35.1%) | 120 (14.9%) vs. 57 (28.2%) | 1019 (63.1%) vs. 219 (54.2%) | 595 (36.9%) vs. 185 (45.8%) | 0.70 (0.55, 0.88), 0.002 |