Table 2 Meta-analysis of the association of VEGF -2578C > A gene polymorphism with lung cancer risk
Genetic contrasts | Group and subgroups | Studies number | Q test P-value | Model selected | OR (95%CI) | P |
|---|---|---|---|---|---|---|
A vs C | Overall | 14 | <0.0001 | Random | 1.26 (1.08,1.46) | 0.003 |
Asian | 12 | 0.001 | Random | 1.33 (1.15,1.55) | 0.0002 | |
Caucasian | 2 | 0.43 | Fixed | 0.90 (0.74,1.11) | 0.33 | |
AA vs CA + CC | Overall | 14 | <0.0001 | Random | 1.29 (0.89,1.89) | 0.18 |
Asian | 12 | 0.0001 | Random | 1.45 (0.92,2.28) | 0.11 | |
Caucasian | 2 | 0.42 | Fixed | 0.78 (0.55,1.12) | 0.18 | |
CC vs CA + AA | Overall | 14 | <0.00001 | Random | 0.72 (0.54,0.95) | 0.02 |
Asian | 12 | <0.00001 | Random | 0.68 (0.50,0.93) | 0.01 | |
Caucasian | 2 | 0.64 | Fixed | 1.06 (0.76,1.47) | 0.74 | |
Sensitivity analysis according to source of the controls from population-based | ||||||
A vs C | Overall | 13 | 0.0008 | Random | 1.30 (1.05,1.72) | 0.0003 |
AA vs CA + CC | Overall | 13 | 0.0002 | Random | 1.39 (0.92,2.08) | 0.12 |
CC vs CA + AA | Overall | 13 | <0.00001 | Random | 0.70 (0.52,0.93) | 0.02 |
Sensitivity analysis according to source of the controls from hospital-based | ||||||
T vs C | Overall | 1 | – | Fixed | 0.85 (0.65,1.10) | 0.21 |
TT vs CT + CC | Overall | 1 | – | Fixed | 0.70 (0.44,1.11) | 0.13 |
CC vs CT + TT | Overall | 1 | – | Fixed | 1.13 (0.74,1.74) | 0.58 |