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Fig. 4 | BMC Medical Genetics

Fig. 4

From: POLE mutations improve the prognosis of endometrial cancer via regulating cellular metabolism through AMF/AMFR signal transduction

Fig. 4

Cellular glucose metabolism was enriched in POLE mutants. a, b GSEA using the canonical pathways, which are annotated pathways mainly from the KEGG, BIOCARTA and REACTOME databases, as the gene sets in the analysis. Gene sets representing glycolysis (a) and gluconeogenesis (b) were enriched in the POLE mutants. c Unsupervised hierarchical clustering with Euclidean distance and ward linkage of expression matrixes from 20 genes inglycometabolis (d) Unsupervised hierarchical clustering with Euclidean distance and ward linkage of expression matrixes from 18 genes in glycolysis. The POLE mutational status for each tumor is depicted directly on top of each column. The black vertical lines represent the samples with POLE mutations. Red represents high gene expression, and blue represents relatively low gene expression

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