Fig. 1

POLE frequently mutates in endometrial cancer. Somatic mutations were analyzed from the exome sequencing data of 530 endometrial cancer samples in the TCGA-UCEC project. a The distribution of the somatic mutation number in the endometrial cancer samples. b Kaplan–Meier curve and log-rank test for endometrial cancer patients based on mutation number. c The number of mutations for all patients (N = 530), patients with POLE mutant (N = 80), and patients with wild type POLE (N = 450). The data were compared using the wilcox.test. The bars represent the mean and SEM. d The OncoPlot of the top 10 mutated genes and POLE. The upper barplot indicates the number of mutations per patient, while the right barplot shows the number of mutations per gene. The mutation types were added as annotations at the bottom. Variants annotated as Multi_Hit are genes that mutated more than once in the same sample. e The pie chart of mutations of POLE occurring in multiple exons. f The lollipopPlot of POLE. The amino acid axis is labeled for domain. The mutation types were added as annotations at the bottom