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Table 3 Association of genetic polymorphisms of HTR2A gene and risk of hypertension

From: Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study

SNP

Crude

p

Model 1

p

Model 2

p

Cohort A

 rs7330636

GG

1.000

 

1.000

 

1.000

 

GA

0.725 (0.540–0.974)

0.033

0.725 (0.538–0.976)

0.034

0.644 (0.437–0.949)

0.026

AA

1.403 (0.271–7.255)

0.686

1.520 (0.292–7.922)

0.619

1.415 (0.206–9.735))

0.724

 rs9590999

CC

1.000

 

1.000

 

1.000

 

CT

0.767 (0.610–0.965)

0.023

0.757 (0.601–0.953)

0.018

0.738 (0.551–0.989)

0.042

TT

0.921 (0.700–1.212

0.921

0.914 (0.692–1.205)

0.522

0.880 (0.624–1.239)

0.463

 rs2183057

AA

1.000

 

1.000

 

1.000

 

AG

1.054 (0.856–1.298)

0.620

1.067 (0.856–1.316)

0.546

1.131 (0.865–1.479)

0.369

GG

1.500 (1.109–2.030)

0.009

1.500 (1.106–2.034)

0.009

1.448 (0.990–2.118)

0.056

 rs4942595

TT

1.000

 

1.000

 

1.000

 

TC

0.757 (0.603–0.952)

0.017

0.748 (0.594–0.941)

0.013

0.739 (0.552–0.989)

0.042

CC

0.919 (0.699–1.209)

0.547

0.911 (0.692–1.201)

0.510

0.907 (0.645–1.276)

0.574

 rs4531630

AA

1.000

 

1.000

 

1.000

 

AG

0.844 (0.672–1.060)

0.144

0.834 (0.663–1.050)

0.122

0.792 (0.592–1.059)

0.115

GG

0.718 (0.544–0.947)

0.019

0.705 (0.533–0.933)

0.015

0.658 (0.462–0.938)

0.021

 rs17069883

AA

1.000

 

1.000

 

1.000

 

AC

1.196 (0.955–1.497)

0.119

1.197 (0.954–1.502)

0.121

1.197 (0.896–1.598)

0.224

CC

1.426 (1.080–1.882)

0.012

1.449 (1.095–1.916)

0.009

1.447 (1.018–2.056)

0.040

 rs4942578

CC

1.000

 

1.000

 

1.000

 

CA

0.991 (0.806–1.220)

0.935

1.007 (0.816–1.241)

0.950

1.054 (0.808–1.376)

0.696

AA

1.264 (0.941–1.699)

0.120

1.288 (0.956–1.736)

0.096

1.562 (1.072–2.275)

0.020

Cohort B

 rs4942578

CC

1.000

 

1.000

 

1.000

 

CA

0.969 (0.871–1.079)

0.569

0.979 (0.876–1.094)

0.710

0.894 (0.759–1.053)

0.180

AA

0.926 (0.793–1.081)

0.328

0.949 (0.808–1.114)

0.521

0.735 (0.582–0.929)

0.010

 rs985933

AA

1.000

 

1.000

 

1.000

 

AG

0.999 (0.893–1.117)

0.986

1.013 (0.902–1.138)

0.824

1.057 (0.892–1.252)

0.521

GG

0.924 (0.799–1.069)

0.289

0.922 (0.793–1.073)

0.293

0.789 (0.631–0.986)

0.037

 rs4941573

TT

1.000

 

1.000

 

1.000

 

TC

1.106 (0.979–1.249)

0.106

1.137 (1.001–1.290)

0.048

1.327 (1.101–1.599)

0.003

CC

1.021 (0.886–1.176)

0.774

1.033 (0.891–1.196)

0.670

1.113 (0.896–1.383)

0.332

 rs6313

GG

1.000

 

1.000

 

1.000

 

GA

1.114 (0.987–1.257)

0.079

1.157 (1.021–1.311)

0.023

1.365 (1.135–1.643)

0.001

AA

1.024 (0.889–1.179)

0.745

1.042 (0.899–1.206)

0.586

1.130 (0.911–1.403)

0.267

 rs1328685

TT

1.000

 

1.000

 

1.000

 

TC

0.948 (0.817–1.100)

0.478

0.939 (0.805–1.096)

0.427

0.982 (0.786–1.228)

0.875

CC

0.570 (0.271–1.199)

0.138

0.544 (0.252–1.175)

0.121

0.292 (0.097–0.883)

0.029

 rs2567675

TT

1.000

 

1.000

 

1.000

 

TC

0.898 (0.807–0.999)

0.047

0.868 (0.776–0.969)

0.012

0.832 (0.708–0.979)

0.027

CC

0.911 (0.721–1.151)

0.435

0.880 (0.690–1.123)

0.305

0.799 (0.561–1.138)

0.214

  1. Model 1 was adjusted for gender, smoking status, alcohol consumption, regular exercise and age. Model 2 was adjusted for Model 1 and systolic blood pressure, total cholesterol and baseline body mass index additionally