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Table 3 Exon 8 FVL stratification with clinical variables

From: Effects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsia

 Exon 8 digest  
PEPreg. normoNon-preg. NormoPE x Preg. normoPE x preg. Normo x non-preg normo
Age (years)30.0 ± 6.3(7)29.3 ± 5.0(12)44.3 ± 7.8(10)0.7920p < 0.001
BMI (Kg/m2)30.2 ± 8.5(6)28.7 ± 3.5(9)27.7 ± 5.6(10)0.64000.7099
SBP (mmHg)149.5 ± 22.6(4)99.2 ± 4.6(4)121.4 ± 15.8(10)0.00480.0018
DBP (mmHg)89.8 ± 17.5(4)62.6 ± 7.1 (4)77.3 ± 10.6(10)0.02800.0176
ALT (U/L)6.9 ± 2.7 (9)6.1 ± 2.1 (5)13.1 ± 4.3(7)0.57910.0015
AST (U/L)25.4 ± 9.8 (9)12.9 ± 2.7 (5)23.9 ± 4.7 (7)0.01760.0159
Creatinine (μmol/L)61.6 ± 14.0 (9)48.8 ± 5.5 (5)66.8 ± 5.9 (7)0.07700.0240
Total Chol (mmol/L)5.5 ± 1.4 (9)4.2 ± 1.4 (5)4.4 ± 0.7 (7)0.12180.1111
TG (mmol/L)1.6 ± 0.3 (9)2.3 ± 0.8 (5)0.5 ± 0.2 (7)0.0335p < 0.0001
HDL (mmol/L)1.5 ± 0.4 (9)0.9 ± 0.4 (5)0.7 ± 0.3(7)0.01970.0012
LDL (mmol/L)4.2 ± 1.4 (9)3.5 ± 1.4 (5)2.5 ± 0.8 (7)0.38770.0436
LDH (U/L)321.7 ± 124.6 (9)222.2 ± 50.5 (5)317.0 ± 107.8 (7)0.11770.2296
Uric acid (μmol/L)289.1 ± 121.0 (9)222.0 ± 50.5 (5)165.7 ± 69.9 (7)0.26550.0527
Wbc (109/L)11.5 ± 4.8 (6)8.0 ± 1.5 (12)5.8 ± 1.4 (11)0.03090.0005
Rbc (1012/L)4.4 ± 0.7 (6)3.9 ± 0.5 (12)4.5 ± 0.3 (11)0.09850.0161
Hb (g/dL)12.5 ± 1.7 (6)10.3 ± 3.1 (12)13.0 ± 0.6 (11)0.12790.0167
Plt (109/L)283.5 ± 66.2 (6)212.7 ± 46.0(12)298.2 ± 56.8 (11)0.01720.0023
Urine Protein70.8 ± 105.9 (7)11.4 ± 5.0 (11)5 (0)0.0769 
No. of preg.3.7 ± 2.1 (6)2.7 ± 1.3 (11) 0.2403 
No. of prev. Birth2.2 ± 1.9 (6)1.2 ± 0.8 (11) 0.1436 
Birth weight1300.0 ± 1168.0 (5)2716.7 ± 694.0 (6) 0.0337 
  1. After multiple testing correction, age, SBP, Alt, TG, HDL, wbc and Plt remained significant. Body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), aspartate transferase (AST), alanine transferase (ALT), total cholesterol (Total Chol), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), lactate dehydrogenase (LDH), white blood cell (wbc), red blood cell (rbc), haemoglobin (Hb), platelet (Plt), number of pregnancies (No. of preg.), number of previous birth (No. of prev. birth)