Skip to main content

Table 3 Exon 8 FVL stratification with clinical variables

From: Effects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsia

 

Exon 8 digest

  

PE

Preg. normo

Non-preg. Normo

PE x Preg. normo

PE x preg. Normo x non-preg normo

Age (years)

30.0 ± 6.3(7)

29.3 ± 5.0(12)

44.3 ± 7.8(10)

0.7920

p < 0.001

BMI (Kg/m2)

30.2 ± 8.5(6)

28.7 ± 3.5(9)

27.7 ± 5.6(10)

0.6400

0.7099

SBP (mmHg)

149.5 ± 22.6(4)

99.2 ± 4.6(4)

121.4 ± 15.8(10)

0.0048

0.0018

DBP (mmHg)

89.8 ± 17.5(4)

62.6 ± 7.1 (4)

77.3 ± 10.6(10)

0.0280

0.0176

ALT (U/L)

6.9 ± 2.7 (9)

6.1 ± 2.1 (5)

13.1 ± 4.3(7)

0.5791

0.0015

AST (U/L)

25.4 ± 9.8 (9)

12.9 ± 2.7 (5)

23.9 ± 4.7 (7)

0.0176

0.0159

Creatinine (μmol/L)

61.6 ± 14.0 (9)

48.8 ± 5.5 (5)

66.8 ± 5.9 (7)

0.0770

0.0240

Total Chol (mmol/L)

5.5 ± 1.4 (9)

4.2 ± 1.4 (5)

4.4 ± 0.7 (7)

0.1218

0.1111

TG (mmol/L)

1.6 ± 0.3 (9)

2.3 ± 0.8 (5)

0.5 ± 0.2 (7)

0.0335

p < 0.0001

HDL (mmol/L)

1.5 ± 0.4 (9)

0.9 ± 0.4 (5)

0.7 ± 0.3(7)

0.0197

0.0012

LDL (mmol/L)

4.2 ± 1.4 (9)

3.5 ± 1.4 (5)

2.5 ± 0.8 (7)

0.3877

0.0436

LDH (U/L)

321.7 ± 124.6 (9)

222.2 ± 50.5 (5)

317.0 ± 107.8 (7)

0.1177

0.2296

Uric acid (μmol/L)

289.1 ± 121.0 (9)

222.0 ± 50.5 (5)

165.7 ± 69.9 (7)

0.2655

0.0527

Wbc (109/L)

11.5 ± 4.8 (6)

8.0 ± 1.5 (12)

5.8 ± 1.4 (11)

0.0309

0.0005

Rbc (1012/L)

4.4 ± 0.7 (6)

3.9 ± 0.5 (12)

4.5 ± 0.3 (11)

0.0985

0.0161

Hb (g/dL)

12.5 ± 1.7 (6)

10.3 ± 3.1 (12)

13.0 ± 0.6 (11)

0.1279

0.0167

Plt (109/L)

283.5 ± 66.2 (6)

212.7 ± 46.0(12)

298.2 ± 56.8 (11)

0.0172

0.0023

Urine Protein

70.8 ± 105.9 (7)

11.4 ± 5.0 (11)

5 (0)

0.0769

 

No. of preg.

3.7 ± 2.1 (6)

2.7 ± 1.3 (11)

 

0.2403

 

No. of prev. Birth

2.2 ± 1.9 (6)

1.2 ± 0.8 (11)

 

0.1436

 

Birth weight

1300.0 ± 1168.0 (5)

2716.7 ± 694.0 (6)

 

0.0337

 
  1. After multiple testing correction, age, SBP, Alt, TG, HDL, wbc and Plt remained significant. Body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), aspartate transferase (AST), alanine transferase (ALT), total cholesterol (Total Chol), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), lactate dehydrogenase (LDH), white blood cell (wbc), red blood cell (rbc), haemoglobin (Hb), platelet (Plt), number of pregnancies (No. of preg.), number of previous birth (No. of prev. birth)