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Table 2 Allele and genotype frequencies of SLCO1B1 in patients taking aspirin

From: Increased risk of aspirin-induced gastric mucosal erosion in elderly Chinese men harboring SLCO1B1*1b/*1b while using aspirin and an ACEI or ARB concomitantly

Gene

Allele frequencies p† value for HWE

Control

n = 250(%)

Case

n = 286 (%)

p

Genotype

Control

n = 125 (%)

Case

n = 143 (%)

p

SLCO1B1

A = 0.28

78 (31.2)

74 (25.9)

0.172

AA

9 (7.2)

10 (7.0)

0.947

388 A > G

G = 0.72

172 (68.8)

212 (74.1)

 

AG

60 (48)

54 (37.8)

0.091

rs2306283

P† = 0.44

   

GG

56 (44.8)

79 (55.2)

0.088

SLCO1B1

T = 0.79

180 (72.0)

245 (85.7)

<0.001

TT

73 (58.4)

111 (77.6)

0.001

521 T > C

C = 0.21

70 (28.0)

41 (14.3)

 

TC

34 (27.2)

23 (16.1)

0.027

rs4149056

P† = 0.37

   

CC

18 (14.4)

9 (6.3)

0.028

  1. p values from the Chi-squared test. †, Hardy–Weinberg equilibrium (HWE) of allele frequencies at individual loci was assessed by comparing the observed and expected genotype frequencies
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BMC Medical Genetics

ISSN: 1471-2350

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