Association of high sensitive C-reactive protein with coronary heart disease: a Mendelian randomization study

BMC Medical Genetics

Table 2 Association analysis of CRP polymorphisms with CHD incidence

SNP	Genotype	N	Person-years	Incidence density (/10⁴ Person-years)	HR (95% CI)^a
SNP	Genotype	N	Person-years	Incidence density (/10⁴ Person-years)	Additive model	Dominant model	Recessive model
rs10737175	CC	56	12,085.13	46.34	1.03(0.75–1.41)	1.00(0.68–1.48)	1.19(0.55–2.57)
	CT	35	7514.93	46.57	P = 0.873	P = 0.995	P = 0.668
	TT	7	1246.34	56.16
rs1205	CC	34	6872.61	49.47	1.03(0.78–1.36)	0.90(0.60–1.35)	1.26(0.79–2.03)
	CT	43	10,196.32	42.17	P = 0.851	P = 0.615	P = 0.338
	TT	21	3756.4	55.9
rs2808630	TT	71	14,371.91	49.4	0.81(0.55–1.19)	0.80(0.52–1.23)	0.64(0.15–2.72)
	TC	24	5901.37	40.67	P = 0.274	P = 0.300	P = 0.546
	CC	3	563.1	53.28
rs876537	CC	34	6849.88	49.64	1.03(0.78–1.36)	0.91(0.61–1.37)	1.24(0.77–1.99)
	CT	43	10,189.35	42.2	P = 0.848	P = 0.659	P = 0.374
	TT	21	3802.17	55.23

Additive model: wild type vs heterozygote vs mutant
Dominant model: wild type vs heterozygote + mutant
Recessive model: wild type + heterozygote vs mutant
HR hazard ratio, CI interval confidence
^aAdjusted for age, gender, BMI, HDL-C, LDL-C, TC, TG, smoking, drinking, hypertension and T2DM

ISSN: 1471-2350