Table 5 Haplotype frequencies of F5, MTHFR and VEGFA gene variants and linkage disequilibrium analysis

Haplotype

F5: c.1601G > A

F5: c.6665A > G

Cases

Control

Total frequency

OR (95%CI)

p-value

P*

1.

G

A

0.928

0.876

0.902

1.00

–

–

2.

G

G

0.056

0.120

0.088

0.35 (0.17–0.72)

0.0048

0.0144

3.

A

G

0.016

0.004

0.01

7.05 (0.72–69.36)

0.095

0.142

4.

A

A

–

–

–

–

–

–

Haplotype

MTHFR: c.665C > T

MTHFR: c.1286A > C

1.

C

A

0.672

0.528

0.6

1.00

–

–

2.

C

C

0.224

0.432

0.328

0.32 (0.21–0.51)

< 0.0001

0.0006

3.

T

C

0.104

0.04

0.072

2.85 (1.29–6.29)

0.0099

0.0198

4.

T

A

–

–

–

–

–

–

Haplotype

VEGFA: c.*237C > T

VEGFA: c.-2055A > C

1.

C

C

0.552

0.54

0.546

1.00

–

–

2.

C

A

0.364

0.348

0.356

1.26 (0.73–2.17)

0.41

0.41

3.

T

A

0.084

0.112

0.098

0.66 (0.34–1.25)

0.20

0.24

4.

T

C

–

–

–

–

–