Table 4 Association of F5:c.6665A > G, MTHFR: c.665C > T and c.1286A > C genotypes with onset and severity of preeclampsia
SNV | Genotype | Onset of preeclampsia | Severity of preeclampsia | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Early (N = 50) | Late (N = 75) | OR (95% CI) | p-value | P* | Mild (N = 55) | Severe (N = 70) | OR (95% CI) | p-value | P* | ||
F5:c.6665A > G | AA | 43 (34.4%) | 66 (52.8%) | 1.00 | – | – | 50 (40%) | 59 (47.2%) | 1.00 | – | – |
AG | 6 (4.8%) | 8 (6.4%) | 1.27 (0.41–3.40) | 0.68 | 1.02 | 4 (3.2%) | 10 (8%) | 0.46 (0.13–1.56) | 0.21 | 0.84 | |
GG | 1 (0.8%) | 1 (0.8%) | 1.51 (0.09–25.51) | 0.77 | 1.026 | 1 (0.8%) | 1 (0.8%) | 1.12 (0.07–18.81) | 0.94 | 0.94 | |
MTHFR:c.665C > T | CC | 40 (32%) | 62 (49.6%) | 1.00 | – | – | 46 (36.8%) | 56 (44.8%) | 1.00 | – | – |
CT | 8 (6.4%) | 12 (9.6%) | 1.08 (0.40–2.88) | 0.89 | 1.068 | 7 (5.6%) | 13 (10.4%) | 0.65 (0.24–1.77) | 0.40 | 0.96 | |
TT | 2 (1.6%) | 1 (0.8%) | 2.88 (0.25–33.20) | 0.40 | 0.8 | 2 (1.6%) | 1 (0.8%) | 2.20 (0.19–25.5) | 0.53 | 0.908 | |
MTHFR:c.1286A > C | AA | 32 (25.6%) | 29 (23.2%) | 1.00 | – | – | 27 (21.6%) | 34 (27.2%) | 1.00 | – | – |
AC | 8 (6.4%) | 38 (30.4%) | 0.19 (0.08–0.49) | < 0.001 | 0.012 | 15 (12%) | 31 (24.8%) | 0.65 (0.28–1.5) | 0.31 | 0.92 | |
CC | 10 (8%) | 8 (6.4%) | 1.08 (0.37–3.19) | 0.89 | 0.97 | 13 (10.4%) | 5 (4%) | 3.26 (1.03–10.30) | 0.04 | 0.24 | |