Table 3 Allele and genotype frequencies of SNVs in preeclamptics and controls
SNV | Genetic model/ HWE (p) | Allele/Genotype | Cases n (%) | Controls n (%) | OR (95%CI) | p-value | P* |
|---|---|---|---|---|---|---|---|
F5:c.1601G > A |  | G | 246 (98) | 249 (99.6) | 1.00 | 0.2125 | 0.35 |
A | 04 (2) | 01 (0.4) | 4.05 (0.45–36.48) | ||||
N/A | G/G | 121 (96.8) | 124 (99.2) | 1.00 | 0.16 | 0.28 | |
G/A | 4 (3.2) | 1 (0.8) | 4.10 (0.45–37.16) | ||||
|  | HWE (p) | – | 0.85 | 0.96 | – | – |  |
F5:c.6665A > G |  | A | 232 (93) | 219 (88) | 1.00 | 0.0532 | 0.099 |
G | 18 (7) | 31 (12) | 0.55 (0.30–1.00) | ||||
Codominant | A/A | 109 (87.2) | 95 (76) | 1.00 | 0.036 | 0.077 | |
A/G | 14 (11.2) | 29 (23.2) | 0.42 (0.21–0.84) | ||||
G/G | 2 (1.6) | 1 (0.8) | 1.74 (0.16–19.53) | ||||
Dominant | A/A | 109 (87.2) | 95 (76) | 1.00 | 0.021 | 0.053 | |
A/G-G/G | 16 (12.8) | 30 (24) | 0.46 (0.24–0.90) | ||||
Recessive | A/A-A/G | 123 (98.4) | 124 (99.2) | 1.00 | 0.56 | 0.71 | |
G/G | 2 (1.6) | 1 (0.8) | 2.02 (0.18–22.53) | ||||
Overdominant | A/A-G/G | 111 (88.8) | 96 (76.8) | 1.00 | 0.011 | 0.038 | |
A/G | 14 (11.2) | 29 (23.2) | 0.42 (0.21–0.84) | ||||
Log- additive | – | – | – | 0.55 (0.30–1.02) | 0.052 | 0.104 | |
|  | HWE (p) | – | 0.12 | 0.69 | – | – |  |
MTHFR:c.665C > T |  | C | 224 (90) | 240 (96) | 1.00 | 0.0076 | 0.0425 |
T | 26 (10) | 10 (4) | 2.78 (1.31–5.90) | ||||
Codominant | C/C | 102 (81.6) | 116 (92.8) | 1.00 | 0.026 | 0.06 | |
C/T | 20 (16) | 8 (6.4) | 2.84 (1.20–6.73) | ||||
T/T | 3 (2.4) | 1 (0.8) | 3.41 (0.35–33.32) |  | |||
Dominant | C/C | 102 (81.6) | 116 (92.8) | 1.00 | 0.0071 | 0.0497 | |
C/T-T/T | 23 (18.4) | 9 (7.2) | 2.91 (1.29–6.57) | ||||
Recessive | C/C-C/T | 122 (97.6) | 124 (99.2) | 1.00 | 0.3 | 0.42 | |
T/T | 3 (2.4) | 1 (0.8) | 3.05 (0.31–29.72) | ||||
Overdominant | C/C-T/T | 105 (84) | 117 (93.6) | 1.00 | 0.015 | 0.046 | |
C/T | 20 (16) | 8 (6.4) | 2.79 (1.18–6.59) | ||||
Log- additive | – | – | – | 2.48 (1.20–5.13) | 0.0085 | 0.0396 | |
|  | HWE (p) | – | 0.12 | 0.17 | – | – |  |
MTHFR:c.1286A > C |  | A | 168 (67) | 132 (53) | 1.00 | 0.0011 | 0.0308 |
C | 82 (33) | 118 (47) | 0.55 (0.38–0.78) | ||||
Codominant | A/A | 61 (48.8) | 40 (32) | 1.00 | 0.0098 | 0.0392 | |
A/C | 46 (36.8) | 52 (41.6) | 0.58 (0.33–1.02) | ||||
C/C | 18 (14.4) | 33 (26.4) | 0.36 (0.18–0.72) | ||||
Dominant | A/A | 61 (48.8) | 40 (32) | 1.00 | 0.0066 | 0.0616 | |
A/C-C/C | 64 (51.2) | 85 (68) | 0.49 (0.30–0.83) | ||||
Recessive | A/A-A/C | 107 (85.6) | 92 (73.6) | 1.00 | 0.018 | 0.0503 | |
C/C | 18 (14.4) | 33 (26.4) | 0.47 (0.25–0.89) | ||||
Overdominant | A/A-C/C | 79 (63.2) | 73 (58.4) | 1.00 | 0.44 | 0.58 | |
A/C | 46 (36.8) | 52 (41.6) | 0.82 (0.49–1.36) | ||||
Log -additive | – | – | – | 0.60 (0.42–0.84) | 0.0024 | 0.0336 | |
|  | HWE (p) | – | 0.069 | 0.073 | – | – |  |
VEGFA: c.-2055A > C |  | C | 138 (55) | 135 (54) | 1.00 | 0.7876 | 0.8821 |
A | 112 (45) | 115 (46) | 0.95 (0.67–1.35) | ||||
Codominant | C/C | 36 (28.8) | 35 (28) | 1.00 | 0.95 | 0.95 | |
A/C | 66 (52.8) | 65 (52) | 0.99 (0.55–1.76) | ||||
A/A | 23 (18.4) | 25 (20) | 0.89 (0.43–1.86) | ||||
Dominant | C/C | 36 (28.8) | 35 (28) | 1.00 | 0.89 | 0.958 | |
A/C-A/A | 89 (71.2) | 90 (72) | 0.96 (0.55–1.67) | ||||
Recessive | C/C-A/C | 102 (81.6) | 100 (80) | 1.00 | 0.75 | 0.91 | |
A/A | 23 (18.4) | 25 (20) | 0.90 (0.48–1.69) | ||||
Overdominant | C/C-A/A | 59 (47.2) | 60 (48) | 1.00 | 0.9 | 0.93 | |
A/C | 66 (52.8) | 65 (52) | 1.03 (0.63–1.70) | ||||
Log- additive | – | – | – | 0.95 (0.66–1.37) | 0.78 | 0.91 | |
|  | HWE (p) | – | 0.59 | 0.72 | – | – |  |
VEGFA:c.*237C > T |  | C | 229 (92) | 222 (89) | 1.00 | 0.2939 | 0.433 |
T | 21 (8) | 28 (11) | 0.73 (0.40–1.32) | ||||
N/A | C/C | 104 (83.2) | 97 (77.6) | 1.00 | 0.26 | 0.404 | |
C/T | 21 (16.8) | 28 (22.4) | 0.70 (0.37–1.31) | ||||
|  | HWE (p) | – | 0.305 | 0.36 | – | – |  |