Overall and subgroups | NO. | T versus C | TT versus CC | CT versus CC | CT + TT versus CC | TT versus CT + CC | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | PQ | I2(%) | OR (95% CI) | PQ | I2(%) | OR (95% CI) | PQ | I2(%) | OR (95% CI) | PQ | I2(%) | OR (95% CI) | PQ | I2(%) | ||
Total | 17 | 1.16 (1.06, 1.27) | 0 | 75.7 | 1.29 (1.06, 1.56) | 0 | 71.6 | 1.15 (1.01, 1.31) | 0 | 75.4 | 1.20 (1.05, 1.36) | 0 | 76.5 | 1.22 (1.02, 1.45) | 0 | 70.6 |
Ethnicity | ||||||||||||||||
Asians | 16 | 1.18 (1.08, 1.29) | 0 | 75.3 | 1.32 (1.09, 1.59) | 0 | 72.1 | 1.18 (1.03, 1.34) | 0 | 75.9 | 1.23 (1.08, 1.39) | 0 | 76.4 | 1.24 (1.04, 1.47) | 0 | 71.4 |
Caucasians | 1 | 0.74 (0.52, 1.05) | NA | NA | 0.45 (0.13, 1.50) | NA | NA | O.74 (0.49, 1.14) | NA | NA | 0.71 (0.47, 1.08) | NA | NA | 0.50 (0.15, 1.66) | NA | NA |
Method | ||||||||||||||||
TaqMan | 9 | 1.07 (0.98, 1.17) | 0.01 | 60.6 | 1.12 (0.92, 1.36) | 0.01 | 63.2 | 1.12 (0.96, 1.31) | 0 | 74.1 | 1.12 (0.98, 1.29) | 0 | 72.6 | 1.06 (0.87, 1.31) | 0 | 70.8 |
MassArray | 2 | 1.36 (1.16, 1.60) | 0.28 | 13.8 | 1.96 (1.39, 2.75) | 0.53 | 0 | 1.29 (1.05, 1.57) | 0.32 | 0.4 | 1.39 (1.14, 1.71) | 0.29 | 10.9 | 1.75 (1.26, 2.42) | 0.66 | 0 |
PCR-RFLP | 3 | 1.44 (0.68, 3.05) | 0 | 90.9 | 4.14 (0.21, 80.14) | 0 | 89 | 1.32 (0.66, 2.64) | 0 | 83.7 | 1.45 (0.63, 3.35) | 0 | 89.4 | 3.60 (0.26, 49.72) | 0 | 86.2 |
Others | 3 | 1.17 (1.07, 1.28) | 0.4 | 0 | 1.33 (1.11, 1.61) | 0.42 | 0 | 1.01 (0.68, 1.51) | 0 | 86 | 1.12 (0.84, 1.49) | 0.01 | 77 | 1.33 (1.12, 1.57) | 0.83 | 0 |
Cancer type | ||||||||||||||||
Breast cancer | 5 | 1.29 (1.02, 1.62) | 0 | 86.8 | 1.56 (0.95, 2.56) | 0 | 83 | 1.15 (0.84, 1.55) | 0 | 84.2 | 1.27 (0.94, 1.71) | 0 | 85.7 | 1.48 (0.98, 2.26) | 0 | 80.3 |
Bladder cancer | 3 | 1.01 (0.82, 1.25) | 0.1 | 56.8 | 0.80 (0.40, 1.61) | 0.06 | 64 | 1.20 (0.64, 2.23) | 0 | 90.1 | 1.13 (0.68, 1.88) | 0 | 85.9 | 0.63 (0.22, 1.80) | 0 | 85.1 |
Digestive system cancera | 3 | 1.02 (0.82, 1.26) | 0.04 | 81.6 | 1.05 (0.68, 1.62) | 0.01 | 79.8 | 1.00 (0.79, 1.26) | 0.08 | 61 | 1.01 (0.77, 1.34) | 0.02 | 76.1 | 1.03 (0.76, 1.41) | 0.04 | 68.5 |
Osteosarcoma | 1 | 1.27 (0.98, 1.66) | NA | NA | 1.29 (0.61, 2.71) | NA | NA | 1.53 (1.07, 2.19) | NA | NA | 1.50 (1.05, 2.12) | NA | NA | 1.04 (0.50, 2.13) | NA | NA |
Cervical cancer | 1 | 1.53 (1.17, 2.02) | NA | NA | 2.35 (1.21, 4.57) | NA | NA | 1.50 (1.05, 2.16) | NA | NA | 1.62 (1.15, 2.29) | NA | NA | 1.98 (1.04, 3.78) | NA | NA |
Oral squamous cell carcinoma | 2 | 1.26 (1.11, 1.42) | 0.72 | 0 | 1.63 (1.25, 2.12) | 0.42 | 0 | 1.25 (1.04, 1.50) | 0.65 | 0 | 1.32 (1.11, 1.57) | 0.8 | 0 | 1.42 (1.07, 1.88) | 0.24 | 28.1 |
Lung cancer | 2 | 1.17 (1.03, 1.33) | 0.73 | 0 | 1.44 (1.07, 1.94) | 0.27 | 19.4 | 1.08 (0.84, 1.39) | 0.18 | 44.4 | 1.15 (0.97, 1.37) | 0.47 | 0 | 1.37 (0.89, 2.11) | 0.08 | 67.6 |
Source ofcontrols | ||||||||||||||||
Population-based | 8 | 1.16 (0.98, 1.38) | 0 | 86.5 | 1.36 (0.96, 1.93) | 0 | 82.4 | 1.08 (0.87, 1.33) | 0 | 80.9 | 1.15 (0.92, 1.43) | 0 | 84.7 | 1.30 (0.98, 1.73) | 0 | 77.4 |
Hospital-based | 9 | 1.15 (1.07, 1.24) | 0.18 | 29.6 | 1.29 (1.07, 1.55) | 0.09 | 41.4 | 1.21 (1.03, 1.45) | 0 | 68.5 | 1.23 (1.07, 1.42) | 0.02 | 57.4 | 1.16 (0.93, 1.46) | 0 | 64.7 |
Case sample size | ||||||||||||||||
≥ 500 | 13 | 1.13 (1.04, 1.22) | 0 | 67.1 | 1.27 (1.08, 1.49) | 0 | 63.6 | 1.08 (0.96, 1.20) | 0 | 65.2 | 1.13 (1.01, 1.25) | 0 | 66.4 | 1.25 (1.08, 1.41) | 0.01 | 56.4 |
< 500 | 4 | 1.36 (0.83, 2.23) | 0 | 87.1 | 2.29 (0.31, 16.97) | 0 | 88.2 | 1.57 (0.88, 2.80) | 0 | 83.9 | 1.60 (0.87, 2.92) | 0 | 85.8 | 1.77 (0.23, 13.44) | 0 | 89 |