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Table 4 Overall and subgroups meta-analysis of H19 rs217727 (C > T) polymorphism and cancer risk

From: Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis

Overall and subgroupsNO.T versus CTT versus CCCT versus CCCT + TT versus CCTT versus CT + CC
OR (95% CI)PQI2(%)OR (95% CI)PQI2(%)OR (95% CI)PQI2(%)OR (95% CI)PQI2(%)OR (95% CI)PQI2(%)
Total171.16 (1.06, 1.27)075.71.29 (1.06, 1.56)071.61.15 (1.01, 1.31)075.41.20 (1.05, 1.36)076.51.22 (1.02, 1.45)070.6
Ethnicity
 Asians161.18 (1.08, 1.29)075.31.32 (1.09, 1.59)072.11.18 (1.03, 1.34)075.91.23 (1.08, 1.39)076.41.24 (1.04, 1.47)071.4
 Caucasians10.74 (0.52, 1.05)NANA0.45 (0.13, 1.50)NANAO.74 (0.49, 1.14)NANA0.71 (0.47, 1.08)NANA0.50 (0.15, 1.66)NANA
Method
 TaqMan91.07 (0.98, 1.17)0.0160.61.12 (0.92, 1.36)0.0163.21.12 (0.96, 1.31)074.11.12 (0.98, 1.29)072.61.06 (0.87, 1.31)070.8
 MassArray21.36 (1.16, 1.60)0.2813.81.96 (1.39, 2.75)0.5301.29 (1.05, 1.57)0.320.41.39 (1.14, 1.71)0.2910.91.75 (1.26, 2.42)0.660
 PCR-RFLP31.44 (0.68, 3.05)090.94.14 (0.21, 80.14)0891.32 (0.66, 2.64)083.71.45 (0.63, 3.35)089.43.60 (0.26, 49.72)086.2
 Others31.17 (1.07, 1.28)0.401.33 (1.11, 1.61)0.4201.01 (0.68, 1.51)0861.12 (0.84, 1.49)0.01771.33 (1.12, 1.57)0.830
Cancer type
 Breast cancer51.29 (1.02, 1.62)086.81.56 (0.95, 2.56)0831.15 (0.84, 1.55)084.21.27 (0.94, 1.71)085.71.48 (0.98, 2.26)080.3
 Bladder cancer31.01 (0.82, 1.25)0.156.80.80 (0.40, 1.61)0.06641.20 (0.64, 2.23)090.11.13 (0.68, 1.88)085.90.63 (0.22, 1.80)085.1
 Digestive system cancera31.02 (0.82, 1.26)0.0481.61.05 (0.68, 1.62)0.0179.81.00 (0.79, 1.26)0.08611.01 (0.77, 1.34)0.0276.11.03 (0.76, 1.41)0.0468.5
 Osteosarcoma11.27 (0.98, 1.66)NANA1.29 (0.61, 2.71)NANA1.53 (1.07, 2.19)NANA1.50 (1.05, 2.12)NANA1.04 (0.50, 2.13)NANA
 Cervical cancer11.53 (1.17, 2.02)NANA2.35 (1.21, 4.57)NANA1.50 (1.05, 2.16)NANA1.62 (1.15, 2.29)NANA1.98 (1.04, 3.78)NANA
 Oral squamous cell carcinoma21.26 (1.11, 1.42)0.7201.63 (1.25, 2.12)0.4201.25 (1.04, 1.50)0.6501.32 (1.11, 1.57)0.801.42 (1.07, 1.88)0.2428.1
 Lung cancer21.17 (1.03, 1.33)0.7301.44 (1.07, 1.94)0.2719.41.08 (0.84, 1.39)0.1844.41.15 (0.97, 1.37)0.4701.37 (0.89, 2.11)0.0867.6
Source ofcontrols
 Population-based81.16 (0.98, 1.38)086.51.36 (0.96, 1.93)082.41.08 (0.87, 1.33)080.91.15 (0.92, 1.43)084.71.30 (0.98, 1.73)077.4
 Hospital-based91.15 (1.07, 1.24)0.1829.61.29 (1.07, 1.55)0.0941.41.21 (1.03, 1.45)068.51.23 (1.07, 1.42)0.0257.41.16 (0.93, 1.46)064.7
Case sample size
 ≥ 500131.13 (1.04, 1.22)067.11.27 (1.08, 1.49)063.61.08 (0.96, 1.20)065.21.13 (1.01, 1.25)066.41.25 (1.08, 1.41)0.0156.4
 <  50041.36 (0.83, 2.23)087.12.29 (0.31, 16.97)088.21.57 (0.88, 2.80)083.91.60 (0.87, 2.92)085.81.77 (0.23, 13.44)089
  1. aIncluding colorectal cancer, gastric cancer and pancreatic cancer