Vitamin D receptor ApaI polymorphism associated with progression of liver disease in Vietnamese patients chronically infected with hepatitis B virus

Table 4 Association of ApaI variant with liver disease progression

ApaI SNP	CHB		CHB + LC (non-HCC)		HCC		HCC vs. CHB		HCC vs. non-HCC
ApaI SNP	n	%	n	%	n	%	OR (95%CI)	P*	OR (95%CI)	P*
Codominant
CC	76	42.2	117	44.8	86	52.8	1	Ref	1	Ref
CA	94	52.2	126	48.3	57	35	0.5 (0.3–0.84)	0.004	0.6 (0.4–0.98)	0.04
AA	10	5.6	18	6.9	20	12.3	1.84 (0.7–4.8)	0.206	1.4 (0.7–3.0)	0.189
Dominant
CC	76	42.2	117	44.8	86	52.8	1	Ref	1	Ref
CA + AA	104	57.8	144	55.2	77	47.2	0.62 (0.37–0.94)	0.04	0.72 (0.47–1.1)	0.13
Recessive
CC + CA	170	94.4	243	93.1	143	87.7	1	Ref	1	Ref
AA	10	5.6	18	6.9	20	12.3	2.56 (1.01–6.48)	0.04	1.74 (0.8–3.65)	0.14
Overdominant
CC + AA	86	47.8	135	51.7	106	65	1	Ref	1	Ref
CA	94	52.2	126	48.3	57	35	0.46 (0.27–0.76)	0.0023	0.6 (0.38–0.90)	0.017

CHB Chronic hepatitis B, LC Liver cirrhosis, HCC Hepatocellular carcinoma; Non-HCC, CHB + LC; n = number of chromosomes; OR adjusted Odd Ratio; ORs and P values were calculated by using binary logistic regression model adjusted for age and gender. (*) Logistic regression model adjusted for age and gender. Bold values present the statistical significance

ISSN: 1471-2350