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Table 4 Comparison of parameters in patients with and without gallstones

From: Uridine diphosphate glucuronosyl transferase 1A (UGT1A1) promoter polymorphism in young patients with sickle cell anaemia: report of the first cohort study from Nigeria

Parameter

Patients with gallstones (N = 6)

Median (Range)

Patients without gallstones (N = 95)

Median (Range)

P value

 Total Bilirubin (mg/dl)

6.4 (2.8–8.1)

1.8 (0.4–6.7)

0.0001*

 Unconjugated Bilirubin (mg/dl)

4.7 (0.9–6.3)

0.79 (0.1–5)

0.0007*

 LDH (IU/L)

1004 (592–1860)

794 (197–1750)

0.1263*

 HbF (%)

4.7 (1.3–6.8)

10.2 (0.9–32)

0.0107*

 Hb (g/dl)

7.1 (6.3–8.8)

7.5 (6.2–10)

0.4210*

 Age in years

11.5 (8–16)

9 (2–21)

0.1368*

 Sex

  Male (n = 66)

4

62

1.000†

  Female (n = 35)

2

33

 

Parameter

Patients with gallstones (N = 6)

Median (Range)

Matched peers without gallstones within same UGT1A1 genotype activity group N = 10

Median (Range)

P value

 Total Bilirubin (mg/dl)

6.4 (2.8–8.1)

2.2 (1.9–3.2)

0.0023*

 Unconjugated Bilirubin (mg/dl)

4.7 (0.9–6.3)

1.2 (1.0–2.0)

0.0020*

 LDH (IU/L)

1004 (592–1860)

890 (340–1603)

0.628*

 HbF (%)

4.7 (1.3–6.8)

14.7 (4.2–17.9)

0.022*

 Hb (g/dl)

7.1 (6.3–8.8)

8.0 (6.5–8.9)

0.137*

  1. NB Significant P values are indicated in bold fonts
  2. HbF Fetal hemoglobin, Hb Hemoglobin concentration, LDH Lactate dehydrogenase
  3. * = Mann-Whitney test, † = Fisher’s Exact test