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Table 3 Influence of UGT1A1 (TA) n genotype on clinical events of patients

From: Uridine diphosphate glucuronosyl transferase 1A (UGT1A1) promoter polymorphism in young patients with sickle cell anaemia: report of the first cohort study from Nigeria

Clinical events

a. Low activity UGT1A1 genotypes

N = 25

b. Intermediate activity UGT1A1 genotypes

N = 42

c. Normal activity UGT1A1 genotypes (Wild Type)

N = 25

d. High activity UGT1A1 genotypes

N = 9

P value a vs (b + c + d)

VOC rate per year

2 (0–6)

1.5 (0–6)

1 (0–6)

0 (0–6)

0.2218*

Overt Stroke

1

2

1

0

1.000†

No overt stroke

24

40

24

9

Osteonecrosis

1

2

2

0

1.000†

No osteonecrosis

24

40

23

9

Leg ulcer

0

2

4

0

0.331†

No Leg ulcer

25

40

21

9

Gallstones

5

1

0

0

0.0033†

No Gallstone

20

41

25

9

Priapism (Male only event, N = 66)

     

Priapism

2

3

0

0

0.594†

No Priapism

15

25

16

5

  1. Significant p values are indicated in bold fonts
  2. VOC Vaso-occlussive crisis
  3. * = Mann-Whitney Test, † = Fisher’s exact test