Clinical events | a. Low activity UGT1A1 genotypes N = 25 | b. Intermediate activity UGT1A1 genotypes N = 42 | c. Normal activity UGT1A1 genotypes (Wild Type) N = 25 | d. High activity UGT1A1 genotypes N = 9 | P value a vs (b + c + d) |
---|---|---|---|---|---|
VOC rate per year | 2 (0–6) | 1.5 (0–6) | 1 (0–6) | 0 (0–6) | 0.2218* |
Overt Stroke | 1 | 2 | 1 | 0 | 1.000†|
No overt stroke | 24 | 40 | 24 | 9 | |
Osteonecrosis | 1 | 2 | 2 | 0 | 1.000†|
No osteonecrosis | 24 | 40 | 23 | 9 | |
Leg ulcer | 0 | 2 | 4 | 0 | 0.331†|
No Leg ulcer | 25 | 40 | 21 | 9 | |
Gallstones | 5 | 1 | 0 | 0 | 0.0033†|
No Gallstone | 20 | 41 | 25 | 9 | |
Priapism (Male only event, N = 66) |  |  |  |  |  |
Priapism | 2 | 3 | 0 | 0 | 0.594†|
No Priapism | 15 | 25 | 16 | 5 |