Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

Li, Juan; Sun, Li; Sun, Jinghui; Yan, Min

doi:10.1186/s12881-019-0896-6

BMC Medical Genetics

Table 5 Pooled analyses of the association between VDR rs731236 polymorphism and susceptibility to psoriasis

From: Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

Models	M	I²	P _{heterogeneity}	Stratification	case/control (N)	OR [95% CI]	P _association	BH
allele C vs. T	R	47.5%	0.034	overall	1690/1857 (12)	0.91 [0.75~1.10]	0.325	0.690
		57.2%	0.053	Asian	941/837 (5)	0.91 [0.58~1.43]	0.689	0.798
		47.4%	0.090	Caucasian	699/970 (6)	0.87 [0.70~1.08]	0.216	0.629
		47.7%	0.045	PB	1143/1436 (10)	0.90 [0.73~1.12]	0.341	0.524
		49.7%	0.137	China	776/682 (3)	1.01 [0.62~1.64]	0.962	0.974
		73.1%	0.024	Turkey	206/256 (3)	0.93 [0.54~1.61]	0.806	0.824
		45.7%	0.056	P_HWE > 0.05	1383/1675 (10)	0.90[0.72~1.11]	0.324	0.389
		57.4%	0.021	PCR-RFLP	806/907 (8)	0.88 [0.68~1.14]	0.360	0.744
CC vs. TT	F	38.2%	0.114	overall	1325/1508 (9)	0.92[0.67~1.25]	0.581	0.690
		0.0%	0.460	Asian	781/568 (3)	0.80[0.24~2.66]	0.717	0.798
		58.7%	0.046	Caucasian	494/890 (5)	0.87 [0.62~1.22]	0.419	0.629
		43.7%	0.087	PB	983/1167 (8)	0.90 [0.66~1.24]	0.524	0.524
		73.8%	0.022	Turkey	206/256 (3)	1.05 [0.68~1.81]	0.868	0.974
		0.0%	0.511	China	666/499 (2)	1.24 [0.28~5.53]	0.775	0.824
		24.8%	0.231	P_HWE > 0.05	1223/1406 (8)	0.79[0.56~1.12]	0.183	0.386
		59.8%	0.029	PCR-RFLP	551/741 (6)	0.88 [0.61~1.28]	0.499	0.749
TC vs. TT	R	46.8%	0.043	overall	1485/1777 (11)	0.95[0.72~1.24]	0.690	0.690
		51.5%	0.083	Asian	941/837 (5)	0.90[0.58~1.42]	0.658	0.798
		61.0%	0.036	Caucasian	494/890 (5)	0.98[0.63~1.51]	0.918	0.918
		46.6%	0.051	PB	1143/1436 (10)	0.91[0.68~1.22]	0.523	0.524
		50.4%	0.133	China	776/682 (3)	0.97[0.58~1.63]	0.915	0.974
		73.1%	0.024	Turkey	206/256 (3)	1.26 [0.53~2.99]	0.593	0.824
		15.7%	0.299	P_HWE > 0.05	1383/1675 (10)	0.85[0.69~1.06]	0.155	0.386
		56.3%	0.033	PCR-RFLP	601/827 (7)	0.88 [0.61~1.28]	0.988	0.988
TC + CC vs. TT	R	50.7%	0.027	overall	1485/1777 (11)	0.94[0.71~1.23]	0.636	0.690
		56.0%	0.059	Asian	941/837 (5)	0.90[0.57~1.44]	0.671	0.798
		61.4%	0.035	Caucasian	494/890 (5)	0.93[0.62~1.40]	0.733	0.880
		49.6%	0.037	PB	1143/1436 (10)	0.90 [0.67~1.19]	0.453	0.524
		51.4%	0.128	China	776/682 (3)	0.99[0.59~1.66]	0.974	0.974
		76.8%	0.013	Turkey	206/256 (3)	1.12 [0.47~2.68]	0.794	0.824
		32.9%	0.145	P_HWE > 0.05	1383/1675 (10)	0.86[0.67~1.09]	0.205	0.386
		61.7%	0.016	PCR-RFLP	601/827 (7)	0.96 [0.63~1.45]	0.843	0.988
CC vs. TT + TC	F	4.4%	0.398	overall	1325/1508 (9)	0.91[0.69~1.20]	0.487	0.690
		0.0%	0.506	Asian	781/568 (3)	0.85[0.26~2.85]	0.798	0.798
		25.0%	0.254	Caucasian	494/890 (5)	0.86[0.64~1.16]	0.330	0.629
		10.9%	0.345	PB	983/1167 (8)	0.90[0.68~1.19]	0.442	0.524
		0.0%	0.543	China	666/499 (2)	1.30[0.29~5.76]	0.734	0.974
		47.7%	0.148	Turkey	206/256 (3)	0.81 [0.52~1.27]	0.361	0.824
		16.3%	0.301	P_HWE > 0.05	1223/1406 (8)	0.89[0.64~1.23]	0.472	0.472
		27.6%	0.228	PCR-RFLP	551/741 (6)	0.82 [0.59~1.14]	0.228	0.744
carrier C vs. T	F	1.1%	0.430	overall	1485/1777 (11)	0.93[0.80~1.09]	0.380	0.690
		41.4%	0.145	Asian	941/837 (5)	0.92[0.68~1.23]	0.558	0.798
		0.0%	0.617	Caucasian	494/890 (5)	0.92[0.76~1.11]	0.388	0.629
		0.0%	0.492	PB	1143/1436 (10)	0.90[0.77~1.06]	0.223	0.524
		37.9%	0.200	China	776/682 (3)	0.98[0.70~1.38]	0.922	0.974
		16.6%	0.302	Turkey	206/256 (3)	0.96[0.70~1.32]	0.824	0.824
		2.6%	0.415	P_HWE > 0.05	1383/1675 (10)	0.91[0.77~1.07]	0.257	0.386
		11.6%	0.341	PCR-RFLP	601/827 (7)	0.92 [0.75~1.11]	0.372	0.744

M statistical model, R random effect, F fixed effect, P_HWE P-value of Hardy-Weinberg equilibrium, P_{heterogeneity} P-value of Cochrane’s Q statistic for the assessment of heterogeneity, N Number of included case-control studies, OR odds ratio, CI confidence interval, P_association P-value of association,
BH Benjamini & Hochberg-adjusted P_association

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