Table 3 Pooled analyses of the association between VDR rs1544410 polymorphism and susceptibility to psoriasis
From: Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis
Models | M | I2 | P heterogeneity | Stratification | case/control (N) | OR [95% CI] | P association | BH |
|---|---|---|---|---|---|---|---|---|
allele A vs. G | R | 54.9% | 0.009 | overall | 1620/2001 (13) | 1.01 [0.82~1.26] | 0.898 | 0.925 |
71.8% | 0.002 | Asian | 1108/1046 (7) | 1.04 [0.63~1.69] | 0.889 | 0.973 | ||
4.8% | 0.386 | Caucasian | 512/955 (6) | 1.05 [0.89~1.24] | 0.547 | 0.821 | ||
58.2% | 0.008 | PB | 1186/1536 (11) | 0.95 [0.74~1.23] | 0.711 | 0.971 | ||
75.0% | 0.007 | China | 888/790 (4) | 0.82 [0.43~1.54] | 0.533 | 1.000 | ||
61.8% | 0.004 | PHWE > 0.05 | 1478/1791 (11) | 1.00 [0.78~1.30] | 0.973 | 0.973 | ||
60.0% | 0.010 | PCR-RFLP | 736/1051 (9) | 1.02 [0.77~1.36] | 0.898 | 0.898 | ||
AA vs. GG | F | 0.0% | 0.452 | overall | 1416/1769 (11) | 1.26 [0.93~1.73] | 0.151 | 0.925 |
0.0% | 0.478 | Asian | 996/938 (6) | 1.65 [0.79~3.46] | 0.186 | 0.973 | ||
13.5% | 0.328 | Caucasian | 420/831 (5) | 1.19 [0.84~1.68] | 0.339 | 0.821 | ||
7.2% | 0.375 | PB | 1074/1428 (10) | 1.25 [0.91~1.71] | 0.172 | 0.971 | ||
0.0% | 0.981 | China | 776/682 (3) | 1.74 [0.44~6.92] | 0.433 | 1.000 | ||
4.9% | 0.396 | PHWE > 0.05 | 1366/1683 (10) | 1.29 [0.93~1.77] | 0.125 | 0.375 | ||
23.6% | 0.249 | PCR-RFLP | 532/819 (7) | 1.43 [0.97~2.10] | 0.072 | 0.144 | ||
GA vs. GG | F | 41.6% | 0.071 | overall | 1416/1769 (11) | 1.08 [0.85~1.37] | 0.524 | 0.925 |
47.1% | 0.092 | Asian | 996/938 (6) | 1.01 [0.70~1.46] | 0.945 | 0.973 | ||
46.8% | 0.111 | Caucasian | 420/831 (5) | 1.13 [0.83~1.55] | 0.437 | 0.821 | ||
40.7% | 0.086 | PB | 1074/1428 (10) | 1.00 [0.78~1.30] | 0.971 | 0.971 | ||
66.7% | 0.049 | China | 776/682 (3) | 1.00 [0.68~1.48] | 1.000 | 1.000 | ||
47.1% | 0.049 | PHWE > 0.05 | 1366/1683 (10) | 1.09 [0.86~1.38] | 0.496 | 0.744 | ||
0.0% | 0.437 | PCR-RFLP | 532/819 (7) | 1.45 [0.99~2.14] | 0.050 | 0.144 | ||
GA + AA vs. GG | F | 44.1% | 0.057 | overall | 1416/1769 (11) | 1.12 [0.89~1.40] | 0.335 | 0.925 |
54.3% | 0.053 | Asian | 996/938 (6) | 1.12 [0.79~1.58] | 0.535 | 0.973 | ||
42.5% | 0.138 | Caucasian | 420/831 (5) | 1.12 [0.83~1.50] | 0.462 | 0.821 | ||
43.7% | 0.067 | PB | 1074/1428 (10) | 1.05 [0.82~1.34] | 0.710 | 0.971 | ||
65.6% | 0.055 | China | 776/682 (3) | 1.05 [0.72~1.53] | 0.813 | 1.000 | ||
49.0% | 0.039 | PHWE > 0.05 | 1366/1683 (10) | 1.13 [0.90~1.41] | 0.307 | 0.614 | ||
16.6% | 0.303 | PCR-RFLP | 532/819 (7) | 1.46 [1.03~2.08] | 0.035 | 0.144 | ||
AA vs. GG + GA | F | 40.7% | 0.070 | overall | 1528/1877 (12) | 0.98 [0.79~1.22] | 0.866 | 0.925 |
59.1% | 0.023 | Asian | 1108/1046 (7) | 0.94 [0.65~1.37] | 0.765 | 0.973 | ||
0.0% | 0.430 | Caucasian | 420/831 (5) | 1.00 [0.77~1.30] | 0.998 | 0.998 | ||
45.1% | 0.051 | PB | 1186/1536 (11) | 0.98 [0.79~1.21] | 0.823 | 0.971 | ||
24.7% | 0.263 | China | 888/790 (4) | 0.50 [0.28~0.88] | 0.901 | 1.000 | ||
46.0% | 0.047 | PHWE > 0.05 | 1478/1791 (11) | 0.99 [0.79~1.23] | 0.018 | 0.108 | ||
60.6% | 0.013 | PCR-RFLP | 644/927 (8) | 0.95 [0.75~1.20] | 0.680 | 0.898 | ||
carrier A vs. G | F | 34.8% | 0.112 | overall | 1528/1877 (12) | 1.01 [0.86~1.18] | 0.925 | 0.925 |
60.1% | 0.020 | Asian | 1108/1046 (7) | 1.00 [0.76~1.30] | 0.973 | 0.973 | ||
0.0% | 0.767 | Caucasian | 420/831 (5) | 1.01 [0.83~1.24] | 0.887 | 0.998 | ||
31.5% | 0.147 | PB | 1186/1536 (11) | 0.97 [0.82~1.15] | 0.737 | 0.971 | ||
68.3% | 0.024 | China | 888/790 (4) | 0.84 [0.61~1.16] | 0.285 | 1.000 | ||
40.6% | 0.078 | PHWE > 0.05 | 1478/1791 (11) | 1.01 [0.86~1.19] | 0.895 | 0.973 | ||
39.5% | 0.115 | PCR-RFLP | 644/927 (8) | 1.02 [0.84~1.25] | 0.815 | 0.898 |