Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

Li, Juan; Sun, Li; Sun, Jinghui; Yan, Min

doi:10.1186/s12881-019-0896-6

BMC Medical Genetics

Table 2 Pooled analyses of the association between VDR rs7975232 polymorphism and susceptibility to psoriasis

From: Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

Models	M	I²	P _{heterogeneity}	Stratification	case/control (N)	OR [95% CI]	P _association	BH
allele C vs. A	R	74.2%	< 0.001	overall	1654/1991 (13)	1.05 [0.85~1.30]	0.640	0.960
		83.4%	< 0.001	Asian	1212/1153 (8)	0.980 [0.70~1.38]	0.921	0.921
		6.4%	0.361	Caucasian	392/788 (4)	1.16 [0.96~1.39]	0.123	0.346
		74.6%	< 0.001	PB	1312/1650 (12)	1.02 [0.81~1.30]	0.849	0.856
		57.4%	0.071	China	888/790 (4)	1.26 [0.99~1.61]	0.065	0.195
		75.8%	< 0.001	P_HWE > 0.05	1604/1941 (12)	1.07 [0.85~1.33]	0.567	0.740
		76.2%	< 0.001	PCR-RFLP	770/1041 (9)	0.93 [0.69~1.27]	0.668	0.819
CC vs. AA	R	55.6%	0.008	overall	1654/1991 (13)	1.11 [0.76~1.64]	0.585	0.960
		71.9%	0.001	Asian	1212/1153 (8)	0.91 [0.48~1.71]	0.761	0.921
		0.0%	0.653	Caucasian	392/788 (4)	1.31 [0.91~1.90]	0.147	0.346
		55.7%	0.010	PB	1312/1650 (12)	1.04 [0.69~1.59]	0.838	0.856
		72.6%	0.012	China	888/790 (4)	1.11 [0.76~1.64]	0.718	0.718
		59.3%	0.005	P_HWE > 0.05	1604/1941 (12)	1.11 [0.74~1.65]	0.617	0.740
		60.5%	0.009	PCR-RFLP	770/1041 (9)	0.93 [0.52~1.66]	0.803	0.819
AC vs. AA	R	61.0%	0.002	overall	1654/1991 (13)	1.15 [0.85~1.54]	0.370	0.960
		68.2%	0.003	Asian	1212/1153 (8)	1.10 [0.70~1.72]	0.683	0.921
		45.9%	0.136	Caucasian	392/788 (4)	1.27 [0.84~1.91]	0.257	0.346
		64.0%	0.001	PB	1312/1650 (12)	1.11 [0.78~1.57]	0.578	0.856
		83.2%	< 0.001	China	888/790 (4)	1.15 [0.64~2.07]	0.638	0.718
		60.6%	0.003	P_HWE > 0.05	1604/1941 (12)	1.20 [0.89~1.63]	0.235	0.478
		62.2%	0.007	PCR-RFLP	770/1041 (9)	0.94 [0.58~1.54]	0.819	0.819
AC + CC vs. AA	R	63.5%	0.001	overall	1654/1991 (13)	1.15 [0.86~1.54]	0.356	0.960
		71.6%	0.001	Asian	1212/1153 (8)	1.06 [0.68~1.66]	0.800	0.921
		43.5%	0.151	Caucasian	392/788 (4)	1.30 [0.89~1.90]	0.179	0.346
		66.0%	0.001	PB	1312/1650 (12)	1.10 [0.78~1.55]	0.595	0.856
		79.1%	0.002	China	888/790 (4)	1.24 [0.75~2.04]	0.402	0.603
		63.6%	0.001	P_HWE > 0.05	1604/1941 (12)	1.20 [0.89~1.62]	0.239	0.478
		65.8%	0.003	PCR-RFLP	770/1041 (9)	0.93 [0.57~1.52]	0.771	0.819
CC vs. AA+AC	R	63.9%	0.001	overall	1654/1991 (13)	1.01 [0.74~1.39]	0.928	0.977
		77.4%	< 0.001	Asian	1212/1153 (8)	0.91 [0.57~1.47]	0.712	0.921
		0.0%	0.943	Caucasian	392/788 (4)	1.19 [0.86~1.64]	0.295	0.346
		63.8%	0.001	PB	1312/1650 (12)	0.97 [0.69~1.35]	0.856	0.856
		20.8%	0.286	China	888/790 (4)	1.26 [0.88~2.14]	0.205	0.410
		66.7%	0.001	P_HWE > 0.05	1604/1941 (12)	1.00 [0.72~1.39]	0.977	0.977
		69.8%	0.001	PCR-RFLP	770/1041 (9)	0.93 [0.60~1.42]	0.727	0.819
carrier C vs. A	F	42.3%	0.053	overall	1654/1991 (13)	1.08 [0.96~1.21]	0.977	0.977
		63.1%	0.008	Asian	1212/1153 (8)	1.08 [0.93~1.25]	0.313	0.921
		0.0%	0.720	Caucasian	392/788 (4)	1.10 [0.90~1.34]	0.346	0.346
		43.6%	0.053	PB	1312/1650 (12)	1.04 [0.92~1.19]	0.507	0.856
		0.0%	0.578	China	888/790 (4)	1.23 [1.03~1.47]	0.020	0.120
		45.9%	0.041	P_HWE > 0.05	1604/1941 (12)	1.09 [0.96~1.22]	0.170	0.478
		46.3%	0.061	PCR-RFLP	770/1041 (9)	0.96 [0.82~1.13]	0.650	0.819

M statistical model, R random effect, F fixed effect, P_HWE P-value of Hardy-Weinberg equilibrium, P_{heterogeneity} P-value of Cochrane’s Q statistic for the assessment of heterogeneity, N Number of included case-control studies, OR odds ratio, CI confidence interval, P_association P-value of association
BH Benjamini & Hochberg-adjusted P_association

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