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Table 4 The frequency of genotypes and alleles of rs3740051 in patients with non-invasive PA and invasive PA

From: SIRT1 (rs3740051) role in pituitary adenoma development

Genotype/allele

Frequency (%)

OR** (CI) p value

Non-invasive PA group, N (%) (n = 58)

Invasive PA group, N (%) (n = 84)

p value*

Genotype

 G/G

2 (3.4)

0 (0)

 

–

 G/A

15 (25.9)

7 (8.3)

0.003*

0.248 (0.094–0.658) 0.005

 A/A

41 (70.7)

77 (91.7)

 

Reference

Allele

 G

19 (16.4)

7 (4.2)

< 0.001*

0.229 (0.091–0.575) 0.002

 A

97 (83.6)

161 (95.8)

  
  1. PA pituitary adenoma, p value significance level, OR odds ratio, CI confidence interval.
  2. *Pearson’s χ 2 test
  3. **Odds ratios were evaluated under the codominant and additive genetic models
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BMC Medical Genetics

ISSN: 1471-2350

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