Table 2 Stratified analyses of MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants on overall cancer risk
From: MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not related to risk of cancer
Variables | N | Case/ | OR(95% CI) Ph P | OR(95% CI) Ph P | OR(95% CI) Ph P | OR(95% CI) Ph P | OR(95% CI) Ph P |
|---|---|---|---|---|---|---|---|
Control | M-allele vs. W-allele | MM vs. WW | MW vs. WW | MM + MW vs. WW | MM vs. MW + WW | ||
C-799 T | |||||||
Total | 11 | 4372/5066 | 0.98 (0.92–1.04) 0.068 0.429 | 0.94 (0.82–1.07) 0.097 0.362 | 1.00 (0.92–1.09) 0.193 0.992 | 0.98 (0.90–1.07) 0.086 0.666 | 0.94 (0.83–1.07) 0.249 0.348 |
Ethnicity | |||||||
Asian | 8 | 3784/4540 | 0.95 (0.89–1.01) 0.248 0.125 | 0.89 (0.77–1.02) 0.258 0.102 | 0.98 (0.89–1.08) 0.585 0.682 | 0.96 (0.88–1.04) 0.396 0.322 | 0.90 (0.78–1.03) 0.401 0.111 |
Caucasian | 2 | 537/489 | 1.18 (0.99–1.41) 0.082 0.062 | 1.38 (0.95–1.96) 0.105 0.095 | 1.28 (0.97–1.69) 0.201 0.082 | 1.30 (1.00–1.70) 0.115 0.047 | 1.18 (0.85–1.62) 0.236 0.322 |
Latin | 1 | 51/37 | 0.94 (0.52–1.71) - 0.835 | 0.96 (0.23–3.93) - 0.955 | 0.37 (0.12–1.11) - 0.075 | 0.46 (0.16–1.34) - 0.157 | 1.97 (0.63–6.18) - 0.245 |
Cancer Type | |||||||
BCa | 3 | 816/774 | 0.97 (0.83–1.12) 0.286 0.671 | 0.85 (0.61–1.17) 0.142 0.316 | 1.08 (0.87–1.33) 0.837 0.492 | 1.02 (0.84–1.25) 0.582 0.813 | 0.83 (0.61–1.12) 0.151 0.219 |
Other cancers | 8 | 3556/4292 | 0.99 (0.89–1.11) 0.039 0.898 | 0.96 (0.83–1.11) 0.108 0.578 | 0.99 (0.89–1.09) 0.080 0.763 | 1.00 (0.86–1.16) 0.033 0.965 | 0.97 (0.84–1.11) 0.329 0.631 |
Source of control | |||||||
HB | 5 | 1057/1231 | 1.02 (0.90–1.15) 0.297 0.746 | 0.99 (0.76–1.28) 0.123 0.939 | 1.08 (0.90–1.30) 0.193 0.415 | 1.06 (0.89–1.26) 0.341 0.539 | 0.98 (0.77–1.23) 0.082 0.837 |
PB | 6 | 3315/3835 | 0.98 (0.87–1.10) 0.039 0.705 | 0.92 (0.79–1.08) 0.127 0.310 | 0.98 (0.88–1.08) 0.146 0.662 | 0.99 (0.85–1.14) 0.049 0.844 | 0.93 (0.80–1.08) 0.528 0.328 |
Lys460Thr | |||||||
Total | 5 | 3019/3544 | 0.94 (0.67–1.32) 0.905 0.729 | 0.83 (0.36–1.93) 0.859 0.669 | 1.00 (0.66–1.50) 0.904 0.994 | 0.96 (0.67–1.40) 0.886 0.848 | 0.83 (0.36–1.93) 0.866 0.669 |
Ethnicity/source of control | |||||||
Asian/PB | 5 | 3019/3544 | 0.94 (0.67–1.32) 0.905 0.729 | 0.83 (0.36–1.93) 0.859 0.669 | 1.00 (0.66–1.50) 0.904 0.994 | 0.96 (0.67–1.40) 0.886 0.848 | 0.83 (0.36–1.93) 0.866 0.669 |
Cancer Type | |||||||
BCa | 1 | 375/375 | 0.76 (0.37–1.58) - 0.462 | 0.74 (0.17–3.35) - 0.700 | 0.77 (0.28–2.09) - 0.610 | 0.76 (0.33–1.76) - 0.526 | 0.75 (0.17–3.37) - 0.705 |
Other cancers | 4 | 2644/3169 | 1.00 (0.68–1.46) 0.896 0.462 | 0.88 (0.32–2.42) - 0.799 | 1.05 (0.67–1.65) 0.868 0.823 | 1.02 (0.68–1.54) 0.886 0.919 | 0.87 (0.32–2.42) - 0.796 |
Lys87Glu | |||||||
Total | 3 | 749/1919 | 1.05 (0.93–1.18) 0.968 0.430 | 1.11 (0.88–1.42) 0.953 0.377 | 0.96(0.78–1.18) 0.647 0.722 | 1.01 (0.83–1.22) 0.863 0.928 | 1.13 (0.93–1.38) 0.604 0.222 |
Ethnicity | |||||||
Caucasian | 3 | 749/1919 | 1.05 (0.93–1.18) 0.968 0.430 | 1.11 (0.88–1.42) 0.953 0.377 | 0.96 (0.78–1.18) 0.647 0.722 | 1.01 (0.83–1.22) 0.863 0.928 | 1.13 (0.93–1.38) 0.604 0.222 |
Cancer Type | |||||||
BCa | 2 | 543/1092 | 1.06 (0.91–1.22) 0.841 0.458 | 1.13 (0.85–1.51) 0.810 0.398 | 0.92 (0.72–1.17) 0.544 0.496 | 0.98 (0.78–1.23) 0.745 0.875 | 1.20 (0.94–1.53) 0.508 0.152 |
Other cancers | 1 | 206/827 | 1.03 (0.83–1.28) - 0.756 | 1.07 (0.70–1.66) - 0.745 | 1.08 (0.74–1.59) - 0.684 | 1.08 (0.75–1.56) - 0.678 | 1.02 (0.72–1.43) - 0.921 |
Source of control | |||||||
HB | 2 | 543/1092 | 1.06 (0.91–1.22) 0.841 0.458 | 1.13 (0.85–1.51) 0.810 0.398 | 0.92 (0.72–1.17) 0.544 0.496 | 0.98 (0.78–1.23) 0.745 0.875 | 1.20 (0.94–1.530 0.508 0.152 |
PB | 1 | 206/827 | 1.03 (0.83–1.28) - 0.756 | 1.07 (0.70–1.66) - 0.745 | 1.08 (0.74–1.59) - 0.684 | 1.08 (0.75–1.56) - 0.678 | 1.02 (0.72–1.43) - 0.921 |