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Table 5 Stratification analysis of the association of CYP4F2 polymorphisms with stroke under genetic models

From: Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke

SNP Model Genotype > 61 ≤61 Male Female
OR(95%CI) p-value OR(95%CI) p-value OR(95%CI) p-value OR(95%CI) p-value
rs3093193 allele C 1.00   1.00   1.00   1.00  
G 1.34 (1.02–1.77) 0.038 * 1.04 (0.79–1.37) 0.791 1.35 (1.06–1.71) 0.016 * 0.95 (0.69–1.32) 0.757
co-dominant CC 1.00 1.00 1.00 1.00
GC 1.56 (1.02–2.39) 0.101 1.09 (0.74–1.61) 0.657 1.10 (0.79–1.54) 0.567 1.21 (0.76–1.92) 0.421
GG 1.86 (0.89–3.92) 0.040 1.27 (0.64–2.50) 0.494 2.29 (1.21–4.32) 0.011 * 0.64 (0.29–1.41) 0.267
dominant C/C 1.00 1.00 1.00 1.00
G/C-G/G 1.61 (1.07–2.42) 0.022 * 1.12 (0.77–1.63) 0.551 1.24 (0.90–1.71) 0.195 1.08 (0.70–1.68) 0.731
recessive C/C-G/C 1.00 1.00 1.00 1.00
G/G 1.50 (0.73–3.05) 0.268 1.21 (0.63–2.33) 0.560 2.19 (1.18–4.05) 0.013 * 0.58 (0.27–1.23) 0.157
log-additive 1.44 (1.05–1.98) 0.024 * 1.11 (0.83–1.49) 0.472 1.31 (1.02–1.69) 0.036 * 0.93 (0.67–1.31) 0.693
rs12459936 allele C    1.00   1.00   1.00  
T 0.73 (0.56–0.94) 0.016 * 0.96 (0.74–1.23) 0.727 0.78 (0.63–0.98) 0.031 * 0.89 (0.65–1.21) 0.449
co-dominant CC 1.00 1.00 1.00 1.00
TC 0.70 (0.44–1.10) 0.117 1.13 (0.73–1.75) 0.582 0.94 (0.64–1.36) 0.729 0.80 (0.49–1.31) 0.383
TT 0.48 (0.26–0.88) 0.018 * 0.79 (0.45–1.38) 0.406 0.65 (0.40–1.05) 0.079 0.86 (0.45–1.62) 0.637
dominant C/C 1.00 1.00 1.00 1.00
T/C-T/T 0.63 (0.41–0.97) 0.036 * 1.03 (0.68–1.56) 0.898 0.85 (0.60–1.22) 0.380 0.82 (0.52–1.30) 0.393
recessive C/C-T/C 1.00 1.00 1.00 1.00
T/T 0.59 (0.34–1.03) 0.060 0.73 (0.45–1.17) 0.189 0.68 (0.44–1.03) 0.068 0.97 (0.55–1.72) 0.922
log-additive 0.69 (0.52–0.93) 0.015 * 0.91 (0.69–1.19) 0.493 0.82 (0.65–1.04) 0.103 0.91 (0.66–1.24) 0.529
rs3093144 allele C 1.00   1.00   1.00   1.00  
T 1.53 (1.09–2.14) 0.013 * 1.06 (0.76–1.48) 0.741 1.36 (1.01–1.82) 0.040 * 1.13 (0.77–1.66) 0.520
co-dominant CC 1.00 1.00 1.00 1.00
TC 1.54 (0.98–2.41) 0.059 1.03 (0.68–1.55) 0.890 1.15 (0.81–1.64) 0.438 1.24 (0.77–2.00) 0.383
TT 2.57 (0.80–8.25) 0.114 1.75 (0.58–5.31) 0.324 4.5 (1.22–16.64) 0.024 * 0.93 (0.31–2.81) 0.902
dominant C/C 1.00 1.00 1.00 1.00
T/C-T/T 1.62 (1.05–2.49) 0.029 * 1.08 (0.73–1.60) 0.569 1.25 (0.89–1.77) 0.198 1.20 (0.76–1.89) 0.445
recessive C/C-T/C 1.00 1.00 1.00 1.00
T/T 2.25 (0.70–7.17) 0.171 1.73 (0.58–5.22) 0.328 4.32 (1.17–15.89) 0.028 * 0.87 (0.29–2.60) 0.807
log-additive 1.56 (1.07–2.27) 0.020 * 1.12 (0.79–1.58) 0.522 1.34 (0.98–1.82) 0.067 1.11 (0.76–1.64) 0.579
  1. p values were calculated from wald test
  2. *Bold values indicate statistical significance (p < 0.05)