From: Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
SNP | Model | Genotype | > 61 | ≤61 | Male | Female | ||||
---|---|---|---|---|---|---|---|---|---|---|
OR(95%CI) | p-value | OR(95%CI) | p-value | OR(95%CI) | p-value | OR(95%CI) | p-value | |||
rs3093193 | allele | C | 1.00 | 1.00 | 1.00 | 1.00 | ||||
G | 1.34 (1.02–1.77) | 0.038 * | 1.04 (0.79–1.37) | 0.791 | 1.35 (1.06–1.71) | 0.016 * | 0.95 (0.69–1.32) | 0.757 | ||
co-dominant | CC | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – | |
GC | 1.56 (1.02–2.39) | 0.101 | 1.09 (0.74–1.61) | 0.657 | 1.10 (0.79–1.54) | 0.567 | 1.21 (0.76–1.92) | 0.421 | ||
GG | 1.86 (0.89–3.92) | 0.040 | 1.27 (0.64–2.50) | 0.494 | 2.29 (1.21–4.32) | 0.011 * | 0.64 (0.29–1.41) | 0.267 | ||
dominant | C/C | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – | |
G/C-G/G | 1.61 (1.07–2.42) | 0.022 * | 1.12 (0.77–1.63) | 0.551 | 1.24 (0.90–1.71) | 0.195 | 1.08 (0.70–1.68) | 0.731 | ||
recessive | C/C-G/C | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – | |
G/G | 1.50 (0.73–3.05) | 0.268 | 1.21 (0.63–2.33) | 0.560 | 2.19 (1.18–4.05) | 0.013 * | 0.58 (0.27–1.23) | 0.157 | ||
log-additive | – | 1.44 (1.05–1.98) | 0.024 * | 1.11 (0.83–1.49) | 0.472 | 1.31 (1.02–1.69) | 0.036 * | 0.93 (0.67–1.31) | 0.693 | |
rs12459936 | allele | C | 1.00 | 1.00 | 1.00 | |||||
T | 0.73 (0.56–0.94) | 0.016 * | 0.96 (0.74–1.23) | 0.727 | 0.78 (0.63–0.98) | 0.031 * | 0.89 (0.65–1.21) | 0.449 | ||
co-dominant | CC | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – | |
TC | 0.70 (0.44–1.10) | 0.117 | 1.13 (0.73–1.75) | 0.582 | 0.94 (0.64–1.36) | 0.729 | 0.80 (0.49–1.31) | 0.383 | ||
TT | 0.48 (0.26–0.88) | 0.018 * | 0.79 (0.45–1.38) | 0.406 | 0.65 (0.40–1.05) | 0.079 | 0.86 (0.45–1.62) | 0.637 | ||
dominant | C/C | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – | |
T/C-T/T | 0.63 (0.41–0.97) | 0.036 * | 1.03 (0.68–1.56) | 0.898 | 0.85 (0.60–1.22) | 0.380 | 0.82 (0.52–1.30) | 0.393 | ||
recessive | C/C-T/C | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – | |
T/T | 0.59 (0.34–1.03) | 0.060 | 0.73 (0.45–1.17) | 0.189 | 0.68 (0.44–1.03) | 0.068 | 0.97 (0.55–1.72) | 0.922 | ||
log-additive | – | 0.69 (0.52–0.93) | 0.015 * | 0.91 (0.69–1.19) | 0.493 | 0.82 (0.65–1.04) | 0.103 | 0.91 (0.66–1.24) | 0.529 | |
rs3093144 | allele | C | 1.00 | 1.00 | 1.00 | 1.00 | ||||
T | 1.53 (1.09–2.14) | 0.013 * | 1.06 (0.76–1.48) | 0.741 | 1.36 (1.01–1.82) | 0.040 * | 1.13 (0.77–1.66) | 0.520 | ||
co-dominant | CC | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – | |
TC | 1.54 (0.98–2.41) | 0.059 | 1.03 (0.68–1.55) | 0.890 | 1.15 (0.81–1.64) | 0.438 | 1.24 (0.77–2.00) | 0.383 | ||
TT | 2.57 (0.80–8.25) | 0.114 | 1.75 (0.58–5.31) | 0.324 | 4.5 (1.22–16.64) | 0.024 * | 0.93 (0.31–2.81) | 0.902 | ||
dominant | C/C | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – | |
T/C-T/T | 1.62 (1.05–2.49) | 0.029 * | 1.08 (0.73–1.60) | 0.569 | 1.25 (0.89–1.77) | 0.198 | 1.20 (0.76–1.89) | 0.445 | ||
recessive | C/C-T/C | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – | |
T/T | 2.25 (0.70–7.17) | 0.171 | 1.73 (0.58–5.22) | 0.328 | 4.32 (1.17–15.89) | 0.028 * | 0.87 (0.29–2.60) | 0.807 | ||
log-additive | – | 1.56 (1.07–2.27) | 0.020 * | 1.12 (0.79–1.58) | 0.522 | 1.34 (0.98–1.82) | 0.067 | 1.11 (0.76–1.64) | 0.579 |