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Table 4 Genetic association analysis for the investigated CYP450 candidate gene polymorphisms using different genetic models

From: Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population

Gene SNP ID Category Test Odds Ratio 95% CI Chi square*
CYP19A1 rs7176005 Het (CT) vs Common Hz (CC) 1.51 1–2.27 3.87
Rare Hz (TT) vs Het (CT) 4.68 1.01–21.69 4.57
Rare Hz (TT) vs Common Hz (CC) 7.05 1.55–32.05 8.44
rs6493497 Het (AG) vs Common Hz (GG) 1.39 0.92–2.1 2.43
Rare Hz (AA) vs Het (AG) 4.93 1.06–22.9 4.94
Rare Hz (AA) vs Common Hz (GG) 6.84 1.5–31.13 8.13
rs700519 Het (AG) vs Common Hz (GG) 1.33 0.55–3.22 0.39
Rare Hz (AA) vs Het (AG) NA NA NA
Rare Hz (AA) vs Common Hz (GG) NA NA NA
rs10046 Het (AG) vs Common Hz (GG) 1.05 0.69–1.61 0.05
Rare Hz (AA) vs Het (AG) 0.76 0.45–1.28 1.06
Rare Hz (AA) vs Common Hz (GG) 0.8 0.45–1.4 0.62
rs4646 Het (AC) vs Common Hz (CC) 1.02 0.68–1.51 0.01
Rare Hz (AA) vs Het (AC) 0.98 0.5–1.9 0
Rare Hz (AA) vs Common Hz (CC) 0.99 0.52–1.89 0
CYP2C9 rs1799853 Het (CT) vs Common Hz (CC) 0.88 0.56–1.39 0.3
Rare Hz (TT) vs Het (CT) 0.85 0.29–2.46 0.09
Rare Hz (TT) vs Common Hz (CC) 0.74 0.27–2.05 0.33
CYP2C19 rs4244285 Het (AG) vs Common Hz (GG) 1.52 0.91–2.53 2.58
Rare Hz (AA) vs Het (AG) 2.09 0.21–21.1 0.41
Rare Hz (AA) vs Common Hz (GG) 3.18 0.33–30.84 1.11
CYP1B1 rs10175368 Het (CT) vs Common Hz (CC) 1.34 0.9–2 2.11
Rare Hz (TT) vs Het (CT) 0.78 0.38–1.6 0.46
Rare Hz (TT) vs Common Hz (CC) 1.05 0.53–2.11 0.02
CYP1A2 rs762551 Het (AC)vs Common Hz (AA) 1.14 0.76–1.71 0.42
Rare Hz (CC) vs Het(AC) 0.51 0.28–0.93 4.92
Rare Hz (CC)vs Common Hz(AA) 0.59 0.33–1.06 3.18
  1. *Significant values are indicated in bold (χ2 > 3.84 and p-value< 0.05)
  2. Adjusted p-value (Bonferonni correction) = 0.0045