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Table 3 Descriptive statistics of the breast cancer cohort

From: Novel mutations in actionable breast cancer genes by targeted sequencing in an ethnically homogenous cohort

Description

History of study cases (specimen type: blood)

%

History of study cases (specimen type: tissue)

%

Number of samples

43/52

82.69

9/52

17.31

Age range (years)

 30–39

13/43

30.23

3/9

33.33

 40–49

16/43

37.21

3/9

33.33

 50–70

14/43

32.56

3/9

33.33

Clinical information

 Breast Cancer

23/43

53.49

9/9

100.00

  Stage I

5/23

21.74

0/9

0.00

  Stage II

12/23

52.17

5/9

55.55

  Stage III

6/23

26.09

2/9

22.22

  Stage unknown

N/A

N/A

2/9

22.22

  Grade I

3/23

13.04

–

–

  Grade II

13/23

56.52

–

–

  Grade III

6/23

26.09

–

–

  Grade unknown

1/23

4.35

9/9

100

Breast lump

11/43

25.58

–

–

Breast pain and secretion

5/43

11.63

–

–

No symptoms

4/43

9.30

–

–

Family History

Positive

38/43

88.37

2/9

22.22

Negative

5/43

11.63

3/9

33.33

Unknown

–

–

4/9

44.44

Mutation found(including VUS and Pathogenic)

11/43

25.58

3/9

(1 patient carried 2 mutations. So total number of mutations in 3 patients are 4)

33.33

BRCA1(V + P)

4/43

9.30

1/9

33.33

BRCA2(V + P)

6/43

13.95

1/9

33.33

TP53(P)

–

–

2/9

22.22

ERBB2(V)

1/43

2.32

–

–

  1. Note: V:VUS and P: Pathogenic