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Table 3 Reported cases showing a positive association between irinotecan and hypocalcemia

From: Metastatic colorectal cancer and severe hypocalcemia following irinotecan administration in a patient with X-linked agammaglobulinemia: a case report

Case

Country

Tumor

Stage

Age

Drug treatment

Serum electrolyte abnormalities

Onset time

2003 [43]

United states

Solid tumors

NA

4–21

Cisplatin, irinotecan, amifostine

Hypocalcemia

Within 24 h after 1st treatment

2005 [44, 45]

United states

Colorectal cancer

TxNxM1

34

Cetuximab, irinotecan

Hypocalcemia, hypomagnesemia

8 weeks after 1st treatment

2009 [46]

United states

Colorectal cancer

T3N2M0

77

Cap, irinotecan, bevacizumab

Hypocalcemia, hypophosphatemia, hypokalemia, hypouricemia

5 days after the 11th treatment

2010 [47]

Japan

Colorectal cancer

TxNxM1

61

Cetuximab, irinotecan

Hypocalcemia, hypomagnesemia

NA

2012 [48]

Turkey

Breast cancer

T2N0M0

57

Irinotecan, trastuzumab

Hypokalemia, hypocalcemia, hypomagnesemia

6th week of treatment