Skip to main content

Table 3 Reported cases showing a positive association between irinotecan and hypocalcemia

From: Metastatic colorectal cancer and severe hypocalcemia following irinotecan administration in a patient with X-linked agammaglobulinemia: a case report

Case Country Tumor Stage Age Drug treatment Serum electrolyte abnormalities Onset time
2003 [43] United states Solid tumors NA 4–21 Cisplatin, irinotecan, amifostine Hypocalcemia Within 24 h after 1st treatment
2005 [44, 45] United states Colorectal cancer TxNxM1 34 Cetuximab, irinotecan Hypocalcemia, hypomagnesemia 8 weeks after 1st treatment
2009 [46] United states Colorectal cancer T3N2M0 77 Cap, irinotecan, bevacizumab Hypocalcemia, hypophosphatemia, hypokalemia, hypouricemia 5 days after the 11th treatment
2010 [47] Japan Colorectal cancer TxNxM1 61 Cetuximab, irinotecan Hypocalcemia, hypomagnesemia NA
2012 [48] Turkey Breast cancer T2N0M0 57 Irinotecan, trastuzumab Hypokalemia, hypocalcemia, hypomagnesemia 6th week of treatment