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Fig. 2 | BMC Medical Genetics

Fig. 2

From: Clinical characteristics and mutation Spectrum of NF1 in 12 Chinese families with orbital/periorbital plexiform Neurofibromatosis type 1

Fig. 2

Clinical manifestations of orbital/periorbital plexiform neurofibromatosis (OPPN) patients. a OPPN located in the upper eyelid. Left: Computed tomography (CT) of infiltrative OPPN. Right upper: Magnetic resonance imaging (MRI) of infiltrative OPPN. The arrow indicates the orbital infiltration of OPPN and displacement of the orbital contents. Right below: General view of a dissected OPPN. b Pathological feature of OPPN: abundant collagen fibres and nerve sheaths. Scale bar: 40 μm. c CT images of OPPN resulting in orbital bone destruction. The arrow indicates the area of orbital osteoclasia. d CT images of facial infiltration of OPPN. The arrow indicates the infiltrated area of OPPN. e CT images of intracranial infiltration of OPPN. The arrow indicates the intracranial infiltration. f Upper: corneal ulceration. Below: Surgery-induced symblepharon. g Café au lait spots. h Coexisting extraocular OPPN. i X-ray images showing an enormous mass in the right chest of OPPN patients

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