Table 2 General characteristics description of the included studies
Study (first author/year) | Country | Enrolled population | Anti-HCV | Anti-HBV | Anti-HIV | Case | No-HCC | No.(HCC/no-HCC) | Sample source | Method | HWE | Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amal A. Mohamed/2017 | Egypt | HCV-infected patients | positive | negative | negative | HCC | LC, healthy | 47/94 | blood samples | TaqMan ViiA 7 Real Time PCR System | Yes | 6 |
Chung-Feng Huang/2017 | China | HCV-infected patients | positive | negative | negative | HCC | LC, HCV patients | 58/647 | blood samples | ABI TaqMan® SNP genotyping assays | Yes | 7 |
H. V. Tong/2013 | Vietnam | HBV-infected patients | negative | positive | negative | HCC | LC, CHB, ASYM, non-HBV healthy | 163/776 | blood samples | asymmetrical PCR | Yes | 9 |
Hoang Hai/2017 | Japan | HCV-infected patients | positive | – | – | HCC | no-HCC | 257/1098 | blood samples | TaqMan SNP Genotyping Assays and direct sequencing | Yes | 8 |
Kangmei Chen/2013 | China | HBV-infected patients | negative | positive | negative | HCC | CHB | 506/772 | blood samples | TaqMan assays and 5% samples were randomly selected and directly sequenced | Yes | 9 |
Maria Antonella Burza/2016 | Italy | HCV-infected patients | positive | negative | negative | HCC | LC, no/mild fibrosis | 142/311 | blood samples | TaqMan assays | Yes | 8 |
Paulisally Hau Yi Lo /2013 | Japan | HCV-infected patients | positive | negative | negative | HCC | LC, CHC | 1394/1629 | blood samples | Illumina HumanHap610-Quad BeadChip or invader assay | Yes | 9 |
Vinod Kumar/2011 | Japan | HCV-infected patients | positive | negative | negative | HCC | non-HCV control | 1394/7217 | blood samples | multiplex PCR-based Invader assay and the Illumina HumanHap610-Quad | Yes | 9 |
Vinod Kumar/2012 | Japan | HBV-infected patients | negative | positive | negative | HCC | CHB, non-HBV control | 407/6356 | blood samples | Illumina Human Hap610-Quad and Human Hap550v3/Invader assay system | Yes | 9 |
Giuseppa Augello/2018 | Italy | HCV-infected patients | positive | negative | negative | HCC | LC healthy | 150/335 | blood samples | Competitive Allele-Specific KASPâ„¢ SNP genotyping platform | Yes | 8 |
Christian M. Lange/2013 | Switzerland | HCV-infected patients | positive | negative | negative | HCC | CHC | 64/1860 | blood samples | fluorescent-based competitive allele-specific PCR genotyping system | Yes | 7 |