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Fig. 2 | BMC Medical Genetics

Fig. 2

From: A novel CLCNKB mutation in a Chinese girl with classic Bartter syndrome: a case report

Fig. 2

Renal biopsy in a patient with CBS. Photomicrograph of renal biopsy specimen with HE, PAS (a, b) stain showed mesangial cell and matrix proliferation and PASM stain (c) showed focal segmental glomerulosclerosis. The immunofluorescence examination showed Immunoglobulins (IgM +, IgA +/−) and complements (C3 +/−) deposited in the mesangium and capillary wall (d). Electron microscopy showed focal segmental glomerulosclerosis with glomerular basement membrane thickened, immune complex deposits in mesangial matrix, vacuolar degeneration of tubular epithelial cells, renal interstitial fibrosis and inflammatory cells infiltration appears (e, f). (Arrows show the specific features.) (a, b, c and d 40× magnification; e, f 4000× magnification)

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