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Table 1 Distribution of anaemia and Hb fraction analysis in association with β-globin gene mutations at c.79G > A (CD-26) and at c92 + 5G > C (IVS1nt5) among carrier thalassemia individuals from Bandung, Indonesia

From: Shine & Lal index as a predictor for early detection of β-thalassemia carriers in a limited resource area in Bandung, Indonesia

 

β-globin mutation

 

c.79G > A

(CD-26)

c92 + 5G > C

(IVS1nt5)

P value

Anaemic status

n

(%)

 

n

(%)

  

 Anaemic

7

(25.9)

 

16

(57.1)

 

0.019#

 Not anaemic

20

(74.1)

 

12

(42.9)

  

Hb fractions

Mean

± sd

(min-max)

Mean

± sd

(min-max)

 

 Hb E

24.06%

± 0.95

(22.4–26.5)

–

   

 Hb A2

3.18%

± 0.62

(2.6–3.8)a

4.65%

± 0.77

(4.0–5.6)

< 0.001##

 Hb A

72.51%

± 0.18

(69.7–74.1)

95.23%

± 0.08

(94.4–96.2)

< 0.001##

  1. Note: aHbA2 is normal (2.2–3.2%) and borderline (3.3–3.9%)
  2. Statistical significance is set at p < 0.05; #χ-square test or ##t-test (data normally distributed)
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BMC Medical Genetics

ISSN: 1471-2350

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