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Table 3 Relationship between genotypes/haplotypes and susceptibility to SMA and Inefficient Erythropoiesis (RPI<2)

From: Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum

SMA

RPI < 2.0

Genetic Variants

OR

95% CI

P-value

OR

95% CI

P-value

Genotypes

IL7 (72194 T/C)

  TT a

0.80

0.47–1.34

0.39

0.84

0.37–1.90

0.67

  TC

0.93

0.61–1.42

0.73

1.90

1.09–3.30

0.02

 CC

1.34

0.69–2.58

0.39

5.14

1.20–21.99

0.03

IL7 (−2440 A/G)

  AA

Ref

  

Ref

  

  AG

1.24

0.74–2.09

0.41

1.38

0.63–3.03

0.42

  GG

0.80

0.09–7.13

0.84

Haplotypes

 TA

0.70

0.38–1.29

0.25

0.24

0.06–1.21

0.05

 TG

1.29

0.61–2.71

0.50

1.17

0.40–3.44

0.78

 THAT

1.04

0.69–1.56

0.85

1.90

1.10–3.30

0.02

 CG

0.94

0.48–1.85

0.86

1.66

0.57–4.80

0.35

  1. Data are presented as odd ratios (OR) and 95% confidence interval (CI) determined by bivariate logistic regression analyses controlling for age, sex, HIV-1 and bacteremia status, α-thalassemia, G6PD deficiency, and sickle-cell status. P-values ≤0.050 were considered significant (indicated in bold font). Parasitemic children were categorized into UM (uncomplicated malaria, Hb ≥ 5.0 g/dL, n = 718) and SMA (severe malarial anemia, Hb < 5.0 g/dL, n = 165), and RPI ≥ 2 (n = 64) and RPI < 2.0 (n = 611)
  2. aTo establish the association between TT genotype and SMA and reduced erythropoiesis, the combined TC/CC were used as reference