SMA | RPI < 2.0 |
---|
Genetic Variants | OR | 95% CI | P-value | OR | 95% CI | P-value |
---|
Genotypes |
IL7 (72194 T/C) |
TT a | 0.80 | 0.47–1.34 | 0.39 | 0.84 | 0.37–1.90 | 0.67 |
TC | 0.93 | 0.61–1.42 | 0.73 | 1.90 | 1.09–3.30 |
0.02
|
CC | 1.34 | 0.69–2.58 | 0.39 | 5.14 | 1.20–21.99 |
0.03
|
IL7 (−2440 A/G) |
AA | Ref | | | Ref | | |
AG | 1.24 | 0.74–2.09 | 0.41 | 1.38 | 0.63–3.03 | 0.42 |
GG | 0.80 | 0.09–7.13 | 0.84 | – | – | – |
Haplotypes |
TA | 0.70 | 0.38–1.29 | 0.25 | 0.24 | 0.06–1.21 |
0.05
|
TG | 1.29 | 0.61–2.71 | 0.50 | 1.17 | 0.40–3.44 | 0.78 |
THAT | 1.04 | 0.69–1.56 | 0.85 | 1.90 | 1.10–3.30 |
0.02
|
CG | 0.94 | 0.48–1.85 | 0.86 | 1.66 | 0.57–4.80 | 0.35 |
- Data are presented as odd ratios (OR) and 95% confidence interval (CI) determined by bivariate logistic regression analyses controlling for age, sex, HIV-1 and bacteremia status, α-thalassemia, G6PD deficiency, and sickle-cell status. P-values ≤0.050 were considered significant (indicated in bold font). Parasitemic children were categorized into UM (uncomplicated malaria, Hb ≥ 5.0 g/dL, n = 718) and SMA (severe malarial anemia, Hb < 5.0 g/dL, n = 165), and RPI ≥ 2 (n = 64) and RPI < 2.0 (n = 611)
- aTo establish the association between TT genotype and SMA and reduced erythropoiesis, the combined TC/CC were used as reference