Fig. 4From: Novel NOG (p.P42S) mutation causes proximal symphalangism in a four-generation Chinese familyThree-dimensional model of noggin-BMP7 tetramer. a Alignment of noggin amino-acid sequences from multiple species. The affected amino-acid site affected by our novel mutation is highly conserved during evolution. b Wild-type 3D model of the noggin dimer; BMP7 dimer is on the right. The red arrow indicates position 42 of noggin. c Mutation 3D model. On the left is the noggin dimer with c.124C > T, p.(Pro42Ser) mutation; BMP7 dimer is on the right. The red arrow indicates position 42 of nogginBack to article page