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Fig. 4 | BMC Medical Genetics

Fig. 4

From: Overexpression of MicroRNA-148b-3p stimulates osteogenesis of human bone marrow-derived mesenchymal stem cells: the role of MicroRNA-148b-3p in osteogenesis

Fig. 4

Osteogenic differentiation of human BM-MSCs was increased by miR-148b-3p overexpression. (a-f) Representative micrograph of 14-day incubation of human BM-MSCs exposed to LV-Ctrl, LV-miR-148b-3p or LV-miR-148b-5p. Immunostaining of ALP and ColI with nuclear counterstained (Hoechst) were shown in red and blue respectively. It should be mentioned that EGFP+ cells were in green. (g-h)BM-MSCs overexpressed miR-148b-3p demonstrated 2.2- and 2.5-fold enhancement in ALP and ColI expression respectively compared to other groups. ****shows significant differences (P < 0.0001) between LV-miR-148b-3pwith LV-miR-148b-5p and LV-Ctrl

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BMC Medical Genetics

ISSN: 1471-2350

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