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Table 4 Measurements of benchmarking predictions

From: Protein modeling to assess the pathogenicity of rare variants of SERPINA1 in patients suspected of having Alpha 1 Antitrypsin Deficiency

 

TPR (sensitivity)

TNR (specificity)

PPV

NPV

ACC

BACC

SVM

1.0

0.825

0.720

1.0

0.879

0.913

Polyphen2

0.944

0.925

0.85

0.974

0.931

0.935

  1. TNR True negative rate, TPR True positive rate, PPV Positive predictive value, NPV Negative predictive value, ACC Total accuracy, BACC Balanced accuracy
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BMC Medical Genetics

ISSN: 1471-2350

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