Fig. 3From: Protein modeling to assess the pathogenicity of rare variants of SERPINA1 in patients suspected of having Alpha 1 Antitrypsin DeficiencyStructure of AAT zoomed in on locations of interest. Presented are some of the missense residues predicted to negatively affect the stability of the folded protein. Several of these missense changes are in the tightly packed core of the protein, such as the P289S variant packed tightly near the M221T variant locationBack to article page