A multivariable approach for risk markers from pooled molecular data with only partial overlap

BMC Medical Genetics

Table 3 Top 10 SNPs according to IFs for the combined data analysis (IF_comb) in decreasing order

SNP		IF _comb	IF _A	IF _B	p-value
rs2274095	✘	0.52	0.51	-	0.42
rs722628	✓	0.48	0.22	0.21	0.55
rs7022345	✓	0.44	0.40	0.07	0.02
rs1323398	✓	0.41	0.37	0.10	0.13
rs2792232	✓	0.39	0.32	0.10	0.20
rs1886261	✘	0.35	0.29	-	0.20
rs10974947	✓	0.34	0.42	0.13	0.06
rs4742308	✓	0.34	0.15	0.17	0.31
rs4742247	✓	0.30	0.14	0.06	0.90
rs7018851	✓	0.29	0.19	0.37	0.63

✓ SNP present in both studies
✘ SNP present in study A but not in study B
We additionally report the respective IFs from the analysis of study A (IF_A) and study B (IF_B). Numbers are marked in bold if the IF of the analysis (of study A or study B) is smaller than that of the combined analysis (IF<IF_comb) and in italics if it is greater (IF>IF_comb). For most SNPs, we have IF<IF_comb, for only few we have IF>IF_comb. We further report p-values from univariate logistic regression for each SNP

ISSN: 1471-2350