Table 4 Meta-analysis of the association between the TGF-β1 + 915G/C gene polymorphism with acute rejection risk in renal transplantation
Genetic contrasts | Groups and subgroups | Number of studies | Q test | Model selected | OR (95% CI) | P |
|---|---|---|---|---|---|---|
P value | ||||||
G vs C | Overall | 7 | 0.26 | Fixed | 1.04 (0.79, 1.37) | 0.80 |
Caucasian | 4 | 0.19 | Fixed | 1.06 (0.72, 1.56) | 0.76 | |
Asian | 2 | – | Fixed | 1.47 (0.73, 2.97) | 0.29 | |
African | 1 | – | Fixed | 0.84 (0.52, 1.36) | 0.47 | |
GG vs (GC + CC) | Overall | 8 | 0.11 | Fixed | 1.24 (0.91, 1.69) | 0.17 |
Caucasian | 5 | 0.06 | Random | 1.29 (0.65, 2.55) | 0.47 | |
Asian | 2 | – | Fixed | 1.71 (0.72, 4.06) | 0.22 | |
African | 1 | – | Fixed | 0.96 (0.54, 1.73) | 0.90 | |
CC vs (GC + GG) | Overall | 7 | 0.80 | Fixed | 1.67 (0.84, 3.31) | 0.14 |
Caucasian | 4 | 0.74 | Fixed | 2.31 (0.60, 8.89) | 0.22 | |
Asian | 2 | – | Fixed | 0.93 (0.25, 3.47) | 0.91 | |
African | 1 | – | Fixed | 1.99 (0.72, 5.51) | 0.19 |